Ophthalmic Mydriasis and cycloplegia for refraction
Adult: As homatropine hydrobromide 2% or 5% solution: Instill 1-2 drops into affected eye(s) immediately before the procedure, repeat after 5-10 minutes if necessary. Child: >3 months As homatropine hydrobromide 2% solution: Instill 1 drop into affected eye(s) immediately before the procedure, repeat after 10 minutes if necessary.
Adult: As homatropine hydrobromide 2% or 5% solution: Instill 1-2 drops into affected eye(s) bid or tid, or up to 3-4 hourly as needed. Child: >3 months As homatropine hydrobromide 2% solution: Instill 1 drop into affected eye(s) bid or tid.
This drug may cause drowsiness, blurred vision and sensitivity to light, if affected, do not drive or operate machinery. Remove contact lenses prior to ophthalmic administration and reinsert after 15 minutes.
Symptoms: Flushing, dry skin, rash, blurred vision, rapid/irregular pulse, hypertension, hyperpyrexia, fever, abdominal distention, convulsions, hallucinations, loss of neuro-muscular coordination, CNS depression, circulatory and respiratory failure, paralytic ileus, confusion, psychoses, agitation, delusions, delirium, paranoia, tachycardia, dysrhythmias, seizures, coma, death. Management: Symptomatic and supportive therapy. Maintain a patent airway and assist respiration, if necessary. Keep body surface of infant and children moist.
Enhanced antimuscarinic effect with amantadine, antihistamines, phenothiazine, antipsychotics, and TCA.
Description: Homatropine is an antimuscarinic tertiary amine that blocks the responses of the iris sphincter muscle and the accommodative ciliary muscle from cholinergic stimulation, thus producing pupillary dilatation and paralysis of accommodation. Onset: Within 30-60 minutes.
S01FA05 - homatropine ; Belongs to the class of anticholinergics used as mydriatics and cycloplegics.
Tài liệu tham khảo
Anon. Homatropine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/01/2018.Buckingham R (ed). Homatropine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/01/2018.Homatropine Hydrobromide Ophthalmic Solution (Ocusoft, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/01/2018.Joint Formulary Committee. Homatropine Hydrobromide. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/01/2018.McEvoy GK, Snow EK, Miller J et al (eds). Homatropine Hydrobromide (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 08/01/2018.Pharmaco NZ Ltd. Isopto Eye Drops 2% data sheet July 2014. Medsafe. http://www.medsafe.govt.nz/. Accessed 12/01/2018.