Adverse effects commonly associated with lamivudine include abdominal pain, nausea, vomiting, diarrhoea, headache, fever, rash, alopecia, malaise, insomnia, cough, nasal symptoms, arthralgia, and musculoskeletal pain. Patients taking lamivudine for the treatment of chronic hepatitis B commonly also have increased serum levels of creatinine phosphokinase and alanine aminotransferase.
There have been rare instances of rhabdomyolysis. Pancreatitis has been reported rarely. Neutropenia and anaemia (usually when given with zidovudine), thrombocytopenia, and increases in liver enzymes and rare cases of hepatitis have occurred. Lactic acidosis, usually associated with severe hepatomegaly and steatosis, has been reported during treatment with nucleoside reverse transcriptase inhibitors.