For chronic hepatitis B: The adult dose is 100 mg once daily by mouth. A dose for children aged over 2 years is 3 mg/kg once daily to a maximum daily dose of 100 mg.
Patients with concomitant HIV and hepatitis B infection: The dosage regimen appropriate for HIV should be used.
Administration in renal impairment: Dosage of lamivudine should be reduced in patients with moderate to severe renal impairment (creatinine clearance (CC) below 50 ml/minute).
Adults with chronic hepatitis B infection: CC 30 to 49 ml/minute: 100 mg for the first dose then 50 mg once daily.
CC 15 to 29 ml/minute: 100 mg for the first dose then 25 mg once daily.
CC 5 to 14 ml/minute: 35 mg for the first dose then 15 mg once daily.
CC less than 5 ml/minute: 35 mg for the first dose then 10 mg once daily.
Haemodialysis patients: No further dose adjustment other than in accordance with creatinine clearance is required.
Peritoneal dialysis patients: Not recommended.
Children: Doses should be reduced according to creatinine clearance by the same proportions as in adults.
Method of Administration: Lamone 100 is orally taken without regard to meals.