Oral Hyperphosphataemia in patients with chronic renal failure
Adult: As chewable tab/oral powd: Initially, 0.75-2.25 g daily in 3 divided doses. Maintenance dose: 1.5-3 g daily in divided doses. Max: 3.75 g daily. Dose is adjusted every 2-3 wk according to serum phosphate level.
Should be taken with food. Take w/ or immediately after meals. Chew thoroughly before swallowing. Do not swallow whole.
Patient w/ altered GI anatomy (e.g. diverticular disease, peritonitis, history of GI surgery, GI cancer, GI ulceration), hypomotility disorders (e.g. constipation, diabetic gastroparesis), active peptic ulcer, Crohn's disease, ulcerative colitis. Hepatic impairment. Pregnancy and lactation.
This drug may cause dizziness and vertigo, if affected, do not drive or operate machinery.
Monitor serum Ca, phosphorus levels.
Symptoms: Headache, nausea and vomiting. Management: Supportive treatment.
May reduce bioavailability of quinolones, tetracycline and levothyroxine chloroquine, ketoconazole. May decrease serum concentration of ACE inhibitor, ampicillin, halofantrine.
May produce a radio-opaque appearance on abdominal radiography.
Description: Lanthanum carbonate is a phosphate binder which inhibits the absorption of dietary phosphate from the intestines. It disintegrates in the GI tract to lanthanum ions (La3+) that binds phosphate to make insoluble and unabsorbable lanthanum phosphate complexes, causing a decrease in serum phosphate and Ca levels. Pharmacokinetics: Absorption: Poorly absorbed from the GI tract. Distribution: Plasma protein binding: >99%. Excretion: Mainly via faeces (74%) and urine (<2%). Elimination half-life: 53 hr (plasma); 2-3.6 yr (bone).
V03AE03 - lanthanum carbonate ; Belongs to the class of drugs used in the treatment of hyperkalemia and hyperphosphatemia.
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