Latanoprost + Timolol


Thông tin thuốc gốc
Chỉ định và Liều dùng
Ophthalmic
Ocular hypertension, Open-angle glaucoma
Adult: As eye preparation containing latanoprost 0.005% and timolol 0.5%: Instill 1 drop into the affected eye(s) once daily. Not to be used as an initial therapy.
Chống chỉ định
Reactive airway diseases e.g.bronchial asthma or a history of bronchial asthma, severe COPD. Sinus bradycardia, 2nd or 3rd degree AV block, overt cardiac failure, cardiogenic shock.
Thận trọng
Monitor heart rate and signs of cardiac failure in patients with history of severe cardiac disease. May worsen Prinzmetal angina, severe peripheral and central circulatory disorders and hypotension. Monitor for signs of bronchospasm in asthmatic patients. β-blockers may mask signs and symptoms of acute hypoglycaemia and hyperthyroidism. Prolonged treatment with latanoprost may change eye colour by increasing the amount of brown pigment in the iris especially in patients with mixed coloured irides; regular eye examination is recommended. Caution when used in aphakic patients due to risk of macular oedema. Contact lenses should be removed during application and reinserted at least 15 minutes after application. May cause transient blurring of vision; patients should not drive or operate machinery until this resolves. Pregnancy and lactation.
Phản ứng phụ
Increased iris pigmentation, eye irritation, eye pain, stinging and burning sensation. Rarely, bradycardia, arrhythmia, CHF, bronchospasm and allergic reactions.
Quá liều
Symptoms of systemic timolol overdose: Bradycardia, hypotension, bronchospasm and cardiac arrest. Treatment is symptomatic and supportive. Latanoprost overload can cause ocular irritation and conjunctival hyperaemia, no other ocular or systemic side effects are known. If latanoprost is accidentally ingested orally, gastric lavage may be used. Treatment is symptomatic and supportive.
Tương tác
Additive effect on the intraocular pressure and other systemic effects may occur when used with oral β-blockers, calcium channel blockers, guanethidine, antiarrhythmics, digitalis glycosides or parasympathomimetics. Concurrent use of ≥2 ophthalmic prostaglandin analogues may lead to paradoxical increase in intraocular pressure. Mydriasis may occur when used concurrently with epinephrine. β-blocker may increase hypoglycaemic effect of antidiabetic agents.
Tác dụng
Description: Latanoprost is an analogue of prostaglandin F; it reduces intraocular pressure (IOP) by increasing outflow of aqueous humour. Timolol is a non-selective adrenergic blocker. It lowers IOP by decreasing the formation of aqueous by the ciliary epithelium.
Pharmacokinetics:
Absorption: Latanoprost: Well-absorbed through the cornea; a prodrug that is activated by the esterases in the cornea.
Distribution: Latanoprost: Active metabolite has a small volume of distribution of 0.16 L/kg and protein binding of 87%.
Metabolism: Latanoprost: Active metabolite is mainly metabolised hepatically. Timolol: Largely metabolised in the liver.
Excretion: Latanoprost: Plasma half-life of active metabolite is about 17 minutes and the metabolites are excreted primarily in the urine. Timolol: Plasma half-life is about 6 hr and the metabolites are mainly excreted in the urine.
Bảo quản
Store at 2-8°C. For opened bottles, may store below 25°C.
Phân loại MIMS
Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Latanoprost + Timolol từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2021 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
  • Lacoma-T
  • Xalacom
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in