Lincomycin


Thông tin thuốc gốc
Chỉ định và Liều dùng
Intramuscular
Severe anaerobic infections
Adult: 600 mg 1-2 times daily.
Child: ≥1 mth 10-20 mg/kg daily in divided doses.

Intravenous
Severe anaerobic infections
Adult: 0.6-1 g 2-3 times daily, by slow IV infusion over at least 1 hr. Max: 8 g/day.
Child: ≥1 mth 10-20 mg/kg daily in divided doses.

Oral
Severe anaerobic infections
Adult: 500 mg 3-4 times daily.
Child: ≥1 mth 30-60 mg/kg daily in divided doses.

Subconjunctival
Severe anaerobic infections
Adult: Inject 75 mg (0.25 mL) as a single dose, to maintain sufficient minimum inhibitory concentrations (MICs) in the ocular fluid levels for at least 5 hr.
Renal Impairment
Severe: Reduce to 25-30% of the usual dose.
Cách dùng
Should be taken on an empty stomach. Take w/ full glass of water on an empty stomach 1 hr before or 2 hr after meals.
Hướng dẫn pha thuốc
Intravenous:
Prior to IV admin, dilute each g in at least 100 mL compatible IV soln.
Tương kỵ
Parenteral:
Ampicillin, novobiocin, kanamycin and phenytoin.
Chống chỉ định
Hypersensitivity to lincomycin or clindamycin.
Thận trọng
Patient w/ history of GI disease particularly colitis, history of asthma or significant allergies. Severe renal and/or hepatic impairment. Pregnancy and lactation.
Phản ứng phụ
Nausea, vomiting, diarrhoea, abdominal pain, tenesmus, glossitis, stomatitis, pruritus ani; rash, vaginitis, leucopenia, neutropenia, agranulocytosis, eosinophilia, thrombocytopaenic purpura; transient increases in serum bilirubin, alkaline phosphatase, and AST, jaundice, headache, myalgia, tinnitus, dizziness, vertigo, azotemia, oliguria, proteinuria, hypotension, syncope; reversible increases in serum creatine kinase (CK) and creatine phosphokinase (CPK); induration, and sterile abscess on inj site w/ IM admin. Rarely, erythema multiforme resembling Stevens-Johnson syndrome, exfoliative and vesiculobullous dermatitis, cardiopulmonary arrest, aplastic anaemia, pancytopenia; thrombophlebitis, erythema, pain and swelling w/ IV admin.
Potentially Fatal: Clostridium difficile-associated diarrhoea and colitis, serious anaphylactoid reactions.
IM/IV/Parenteral/Subconjunctival: C
MonitoringParameters
Periodically perform LFTs, kidney function tests and blood cell counts during prolonged therapy.
Tương tác
May potentiate effects of neuromuscular blocking agents (e.g. pancuronium, tubocurarine). Reduced GI absorption w/ kaolin. May antagonise the effect of erythromycin.
Food Interaction
Food reduces the rate and extent of absorption.
Tác dụng
Description: Lincomycin exerts bacteriostatic and bactericidal effects by binding to 50S ribosome subunit. This results in inhibition of protein synthesis, specifically peptide-bond formation, in susceptible organisms.
Pharmacokinetics:
Absorption: Rapidly absorbed from the GI tract (approx 20-35%). Time to peak plasma concentration: W/in 2-4 hr. Food reduces rate and extent of absorption.
Distribution: Widely distributed into tissues including bone and body fluids; poor diffusion into the CSF. Crosses the placenta and enters breast milk.
Metabolism: Partially metabolised in the liver.
Excretion: Via bile, urine, faeces (as unchanged drug and metabolites). Plasma half-life: Approx 5 hr.
Đặc tính

Chemical Structure Image
Lincomycin

Source: National Center for Biotechnology Information. PubChem Database. Lincomycin, CID=3000540, https://pubchem.ncbi.nlm.nih.gov/compound/Lincomycin (accessed on Jan. 22, 2020)

Bảo quản
Store between 20-25°C. Avoid freezing.
Phân loại MIMS
References
Anon. Lincomycin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 17/06/2014.

Buckingham R (ed). Lincomycin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/06/2014.

Lincocin Injection, Solution (Pharmacia and Upjohn Company). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/06/2014.

Lincocin Injection. U.S. FDA. https://www.fda.gov/. Accessed 15/10/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Lincomycin HCl. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 16/06/2014.

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