Depressed patients display a number of symptoms that are associated with the illness itself. It is therefore sometimes difficult to ascertain which symptoms are a result of the illness itself and which are a result of treatment with mirtazapine.
Very common (1/10 ≤ ADR): Metabolism and nutrition: Weight increased, increase in appetite.
Nervous system: Somnolence, sedation, headache.
Gastrointestinal: Dry mouth.
Common (1/100 ≤ ADR <1/10): Psychiatric: Abnormal dreams, confusion, anxiety, insomnia.
Nervous system: Lethargy, dizziness, tremor.
Vascular: Orthostatic hypotension.
Gastrointestinal: Nausea, diarrhea, vomiting, constipation.
Skin and subcutaneous tissue: Exanthema.
Musculo-skeletal and connective tissue: Arthralgia, myalgia, back pain.
General: Oedema peripheral, fatigue.
Uncommon (1/1000 ≤ ADR <1/100): Psychiatric: Nightmares, mania, agitation, hallucinations, psychomotor restlessness (including akathisia, hyperkinesia).
Nervous system: Paraesthesia, restless legs, syncope.
Gastrointestinal: Oral hypoaesthesia.
Rare (1/10000 ≤ ADR <1/1000): Psychiatric: Aggression.
Nervous system: Myoclonus.
Hepatobiliary: Elevations in serum transaminase activities.