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Chỉ định và Liều dùng
Oral
Raynaud's syndrome Adult: Initially, 40 mg 4 times daily, may be increased to 80 mg 4 times daily if necessary. In patients who are exposed to cold temperatures during the daytime: 40 mg 3 hourly during the period when symptoms are most likely to occur. If response is not achieved within 2 weeks, discontinue therapy.
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Suy gan
Active liver disease: Contraindicated.
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Chống chỉ định
Active liver disease.
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Thận trọng
Patient with diabetes mellitus. Elderly.
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Tác dụng không mong muốn
Significant: Rarely, hepatotoxicity (including hepatitis and cholestatic jaundice).
Ear and labyrinth disorders: Vertigo. Gastrointestinal disorders: Diarrhoea, nausea. Nervous system disorders: Headache. Skin and subcutaneous tissue disorders: Rash. Vascular disorders: Facial flushing. |
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Quá liều
Symptom: Hypotension. Management: Put the patient in supine position until the blood pressure has been normalised.
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Tương tác
May potentiate the effect of antihypertensive agents. Hypotensive effect may be increased by TCAs.
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Tác dụng
Description: Moxisylyte is an α-adrenergic blocking agent that has vasodilating activity.
Synonym: thymoxamine. Pharmacokinetics: Absorption: Rapidly absorbed in the gastrointestinal tract. Metabolism: Rapidly metabolised to desacetylmoxisylyte (metabolite I) and desmethyldesacetylmoxisylyte (metabolite II) which are both active metabolites. Excretion: Via the kidneys. Elimination half-life: 1-2 hours. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 4260, Moxisylyte. https://pubchem.ncbi.nlm.nih.gov/compound/Moxisylyte. Accessed Apr. 27, 2021. |
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Bảo quản
Store below 30°C.
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Phân loại MIMS
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Phân loại ATC
C04AX10 - moxisylyte ; Belongs to the class of other peripheral vasodilators.
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Tài liệu tham khảo
Anon. Moxisylyte. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/04/2021. Buckingham R (ed). Moxisylyte Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/04/2021. Joint Formulary Committee. Moxisylyte. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/04/2021. Opilon 40 mg Tablets (Kyowa Kirin Limited). MHRA. https://products.mhra.gov.uk. Accessed 12/04/2021.
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