Thông tin thuốc gốc
Chỉ định và Liều dùng
Adjunct to induce ovulation with gonadotrophins in the treatment of infertility
Adult: 400 mcg bid, given as 1 spray to each nostril in the morning and 1 spray to each nostril in the evening, starting either on the early follicular phase (day 2) or midluteal phase (day 21) of menstrual cycle, continued until down-regulation is achieved. Max treatment duration: 12 wk.

Adult: 200 mcg bid, given as 1 spray (200 mcg) in 1 nostril in the morning and 1 spray in the other nostril in the evening, starting on days 2-4 of menstrual cycle. Dose may be doubled after 2 mth if symptoms persist. Max treatment duration: 6 mth.

Central precocious puberty
Child: 800 mcg bid, given as 2 sprays (400 mcg) into each nostril in the morning and 2 sprays into each nostril in the evening. Dose may be increased up to 600 mcg tid, if necessary depending on response.
Chống chỉ định
Undiagnosed abnormal vag bleeding. Pregnancy and lactation.
Thận trọng
Patient w/ pituitary adenoma, polycystic ovarian disease, psychiatric comorbidities, risk factors for BMD, intercurrent rhinitis; history of seizures, cerebrovascular disorders, CNS anomalies or tumours. Childn.
Phản ứng phụ
Significant: Ovarian cysts, risk of cystic enlargement, decreased BMD, pituitary apoplexy (e.g. sudden headache, CV collapse, vomiting, visual/mental status change); psychiatric events (e.g. emotional lability, irritability, aggression, depression), seizures, convulsions, vag bleeding, breast enlargement.
Nervous: Insomnia, paraesthesia.
CV: Oedema, HTN, hypotension.
Resp: Rhinitis, nasal mucosal irritation.
Genitourinary: Vulvovaginal dryness, vag discharge, uterine haemorrhage, ovarian hyperstimulation syndrome.
Endocrine: Hot flushes, variable libido, artificial menopause, hypertriglyceridaemia, breast atrophy, hypercholesterolaemia, wt gain/loss, oestrogen deficiency.
Haematologic: WBC decrease, eosinophilia.
Musculoskeletal: Myalgia, arthralgia.
Dermatologic: Acne vulgaris, hypertrichosis, body odor, seborrhoea, hirsutism, alopecia.
Immunologic: Hypersensitivity reactions (e.g. chest pain, urticaria, pruritus, dyspnoea, rash).
Others: Hyperphosphataemia, hypocalcaemia.
Monitor BMD (prior to therapy and before retreatment), FSH and LH blood levels, bone age measurement, development or worsening of psychiatric symptoms, menstruation, vag bleeding/spotting.
Tương tác
May enhance the effect of corifollitropin alfa.
Lab Interference
May give misleading result in the diagnostic test for pituitary gonadotropic and gonadal functions up to 4-8 wk after treatment discontinuation.
Tác dụng
Description: Nafarelin is a gonadorelin analogue. It produces an initial phase of stimulation followed by down-regulation of gonadotrophin-releasing hormone receptors, thus reducing the release of FSH and LH, leading to inhibition of androgen and oestrogen production.
Absorption: Rapidly absorbed intranasally. Bioavailability: Approx 3%. Time to peak plasma concentration: W/in 20 min.
Distribution: Plasma protein binding: Approx 80%, mainly to albumin.
Metabolism: Metabolised by peptidases to form metabolites.
Excretion: Via urine (44-55%, approx 3% as unchanged drug); faeces (19-44%). Elimination half-life: Approx 3 hr.
Đặc tính

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Nafarelin, CID=25077405, (accessed on Jan. 22, 2020)

Bảo quản
Store below 25°C. Protect from light. Do not freeze.
Phân loại ATC
H01CA02 - nafarelin ; Belongs to the class of gonadotropin-releasing hormones. Used in hypothalamic hormone preparations.
Anon. Nafarelin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 05/10/2017.

Buckingham R (ed). Nafarelin Acetate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 05/10/2017.

Joint Formulary Committee. Nafarelin. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 05/10/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Nafarelin Acetate. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). Accessed 05/10/2017.

Synarel Spray Metered (G.D. Searle LLC Division of Pfizer Inc). DailyMed. Source: U.S. National Library of Medicine. Accessed 05/10/2017.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Nafarelin từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2021 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in