Neomycin + Polymyxin B + Gramicidin


Thông tin thuốc gốc
Chỉ định và Liều dùng
Ophthalmic
Superficial ocular infections
Adult: Available preparation:
Neomycin 1.75 mg/mL, polymyxin B 10,000 units/mL and gramicidin 0.025 mg/mL

Instill 1-2 drops into affected eye(s) 4 hourly for 7-10 days. For severe cases: 2 drops hourly.
Tương kỵ
Polymyxin B: Inactivated by strong acids and alkalis.
Chống chỉ định
Hypersensitivity to neomycin, polymyxin B or gramicidin, or to any of its component.
Thận trọng
Patient with otitis media. Prolonged use may cause overgrowth of nonsusceptible organisms, including fungi. Pregnancy and lactation.
Phản ứng phụ
Significant: Hypersensitivity reaction (e.g. angioedema, swelling, conjunctival erythema), local sensitisation (e.g. reddening, pruritus, oedema), superinfection (prolonged use).
Eye disorders: Local irritation, stinging or burning sensation, inflammation.
Skin and subcutaneous tissue disorders: Rash, urticaria, vesicular eruption.
Thông tin tư vấn bệnh nhân
Remove contact lenses prior to ophthalmic administration and reinsert after 15 minutes.
MonitoringParameters
Monitor for signs and symptoms of hypersensitivity.
Tương tác
Neomycin and Polymyxin B: Increased risk of respiratory depression and apnoea with neuromuscular blocking agents.
Tác dụng
Description: Neomycin, an aminoglycoside antibacterial, is bactericidal against a variety of gram-positive and gram-negative organisms. It inhibits bacterial protein synthesis by irreversibly binding to the cell’s 30S ribosomal ribonucleic acid subunits.
Polymyxin B, a lipopeptide antibacterial, is effective against a variety of gram-negative organisms. It damages the bacterial cell membrane by binding to the membrane’s phospholipids that causes leakage of intracellular contents.
Gramicidin, a polypeptide antibacterial, is effective against a variety of gram-positive organisms. It damages the bacterial cell membrane by forming channels through the membrane that increases its permeability to inorganic cations.
Pharmacokinetics:
Distribution: Polymyxin B: Widely distributed and extensively bound to cell membranes in the tissues.
Excretion: Neomycin: Via urine. Elimination half-life: 2-3 hours.
Polymyxin B: Via urine (Approx 60% as unchanged drug). Elimination half-life: Approx 6 hours.
Đặc tính

Chemical Structure Image
Neomycin

Source: National Center for Biotechnology Information. PubChem Database. Neomycin, CID=8378, https://pubchem.ncbi.nlm.nih.gov/compound/Neomycin (accessed on Jan. 21, 2020)


Chemical Structure Image
Polymyxin B

Source: National Center for Biotechnology Information. PubChem Database. Polymyxin b, CID=49800004, https://pubchem.ncbi.nlm.nih.gov/compound/Polymyxin-b (accessed on Jan. 21, 2020)

Bảo quản
Store between 15-25°C. Protect from light.
References
Anon. Neomycin Sulfate (EENT). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 13/04/2018.

Anon. Neomycin, Polymyxin B, and Gramicidin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/04/2018.

Anon. Polymyxin B (EENT). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 13/04/2018.

Buckingham R (ed). Gramicidin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/04/2018.

Buckingham R (ed). Neomycin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/04/2018.

Buckingham R (ed). Polymyxin B Sulfate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/04/2018.

Neomycin and Polymyxin B Sulfates and Gramicidin Solution/Drops (A-S Medication Solutions). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/04/2018.

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