Ornidazole


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Amoebic dysentery
Adult: 1,500 mg as a single daily dose in the evening for 3 days. Patients weighing >60 kg: 1,000 mg bid for 3 days.
Child: ≤35 kg: 40 mg/kg as a single daily dose for 3 days; >35 kg: Same as adult dose.

Oral
Giardiasis
Adult: 1,500 mg as a single daily dose in the evening for 1-2 days.
Child: ≤35 kg: 40 mg/kg as a single daily dose for 1-2 days; >35 kg: Same as adult dose.

Oral
Prophylaxis of postoperative anaerobic bacterial infections
Adult: 1,500 mg 12 hours prior to surgery, then 500 mg 12 hourly for 3-5 days postoperatively.

Oral
Amoebiasis
Adult: 500 mg bid for 5-10 days.
Child: ≤35 kg: 25 mg/kg as a single daily dose for 5-10 days; >35 kg: Same as adult dose.

Oral
Trichomoniasis
Adult: Acute cases: 1,500 mg as a single dose to be given in the evening. Chronic cases: 500 mg bid for 5 days. Treat sexual partners concomitantly.
Child: 25 mg/kg as a single dose.
Suy thận
Patients receiving haemodialysis: Give an additional dose of 500 mg (if the daily dose is 2 g daily) or 250 mg (if the daily dose is 1 g daily) before each dialysis.
Suy gan
Severe: Double the interval between doses.
Cách dùng
Should be taken with food.
Chống chỉ định
Hypersensitivity.
Thận trọng
Patient with CNS disease (e.g. multiple sclerosis, epilepsy). Patient undergoing haemodialysis. Hepatic impairment. Children. Pregnancy and lactation.
Tác dụng không mong muốn
Blood and lymphatic system disorders: Rarely, leucopenia.
Ear and labyrinth disorders: Very rarely, vertigo.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, epigastric discomfort, dry mouth. Rarely, impaired sense of taste.
General disorders and administration site conditions: Fatigue.
Hepatobiliary disorders: Jaundice.
Investigations: Abnormal LFT.
Metabolism and nutrition disorders: Loss of appetite.
Nervous system disorders: Very rarely, somnolence, headache, dizziness, tremor, rigidity, coordination impairments, seizures, temporary loss of consciousness, sensory or mixed peripheral neuropathy.
Skin and subcutaneous tissue disorders: Rarely, pruritus and skin reactions.
Thông tin tư vấn bệnh nhân
This drug may cause somnolence, dizziness, or temporary loss of consciousness, if affected, do not drive or operate machinery.
Tương tác
Potentiates the effect of coumarin-type oral anticoagulants. Prolongs the muscle relaxant effect of vecuronium bromide.
Tương tác với thức ăn
Disulfiram-like reaction (e.g. flushing, tachycardia) may occur when taken concomitantly with alcohol.
Tác dụng
Description: Ornidazole, a 5-nitroimidazole derivative, acts via a mechanism that involves preactivation by reduction of the nitro group and production of toxic derivatives and radicals. It is effective against protozoa, such as Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia (Giardia intestinalis), and certain anaerobic bacteria, such as Bacteroides and Clostridium spp., Fusobacterium spp., and anaerobic cocci.
Pharmacokinetics:
Absorption: Rapidly absorbed. Time to peak plasma concentration: Within 3 hours.
Distribution: Widely distributed in body fluids and tissues, including the CSF. Plasma protein binding: Approx 13%.
Metabolism: Metabolised in the liver.
Excretion: Via urine (4% as unchanged drug). Elimination half-life: Approx 13 hours.
Đặc tính

Chemical Structure Image
Ornidazole

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 28061, Ornidazole. https://pubchem.ncbi.nlm.nih.gov/compound/Ornidazole. Accessed May 26, 2022.

Bảo quản
Store at ≤30°C. Protect from light.
Phân loại MIMS
Thuốc diệt amib / Các loại kháng sinh khác
Phân loại ATC
J01XD03 - ornidazole ; Belongs to the class of imidazole derivative antibacterials. Used in the systemic treatment of infections.
P01AB03 - ornidazole ; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases.
Tài liệu tham khảo
Marcus Y, Tal N, Ronen M et al. The Drug Ornidazole Inhibits Photosynthesis in a Different Mechanism Described for Protozoa and Anaerobic Bacteria. Biochem J. 2016 Dec;473(23):4413-4426. doi: 10.1042/BCJ20160433. Accessed 11/03/2022. PMID: 27647935

Anon. Ornidazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/03/2022.

Buckingham R (ed). Ornidazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/03/2022.

Preston CL (ed). Ornidazole Drug Interactions. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 11/03/2022.

Teva Pharma (New Zealand) Limited. Arrow - Ornidazole, 500 mg, Film Coated Tablet data sheet 18 October 2018. Medsafe. http://www.medsafe.govt.nz. Accessed 09/03/2022.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Ornidazole từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2022 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
  • Rabi-Kit
  • Redpharkit
  • Ulcifam
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in