Oxazepam


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Insomnia associated with anxiety
Adult: 15-25 mg given 1 hr before bedtime. Up to 50 mg may be occasionally required.

Oral
Alcohol withdrawal syndrome, Anxiety
Adult: 15-30 mg 3 or 4 times daily.
Elderly: Initially, 10 mg tid, increase up to 10-20 mg 3 or 4 times daily as necessary.
Special Patient Group
Debilitated patient: Initially, 10 mg tid, increase up to 10-20 mg 3 or 4 times daily as necessary.
Renal Impairment
No dosage adjustment needed.
Cách dùng
May be taken with or without food.
Thận trọng
Patient w/ CV or cerebrovascular disease, acute narrow-angle glaucoma, suicidal tendencies, history of drug abuse or acute alcoholism, myasthenia gravis, chronic pulmonary insufficiency or sleep apnoea. Not intended for treatment of psychoses. Avoid abrupt withdrawal. Hepatic and renal impairment. Elderly or debilitated patient. Pregnancy and lactation.
Phản ứng phụ
Sleep and visual disturbances, drowsiness, dizziness, vertigo, lethargy, headache, tremor, ataxia, mild paradoxical reactions (e.g. excitement, stimulation of affect), minor diffuse skin rashes (e.g. morbilliform, maculopapular and urticarial), nausea, oedema, slurred speech, altered libido, GI symptoms. Rarely, transient anterograde amnesia or memory impairment, syncope, leucopenia and hepatic dysfunction including jaundice.
Thông tin tư vấn bệnh nhân
May impair ability to perform hazardous activities requiring mental alertness or physical coordination (e.g. operating machinery, driving).
MonitoringParameters
Monitor resp and CV status. Periodic monitoring of CBC and LFTs.
Quá liều
Symptoms: Drowsiness, mental confusion, lethargy, ataxia, hypotension, hypotonia, resp depression, coma and very rarely, death. Management: Symptomatic and supportive treatment. If ingestion is recent, induce vomiting and/or gastric lavage. Admin of activated charcoal may reduce absorption. Hypotension may be controlled w/ norepinephrine. Flumazenil may be used as an adjunct for proper management but there is a risk of seizure particularly in long-term benzodiazepine users and in TCA overdose.
Tương tác
Additive CNS depressant effects w/ barbiturates, antipsychotics, sedatives/hypnotics, anxiolytics, antidepressants, sedative antihistamines, anticonvulsants, and anaesth. Increased psychic dependence w/ narcotic analgesics. CYP450 inhibitors may enhance benzodiazepine activity.
Food Interaction
Enhanced sedative effects w/ alcohol.
Tác dụng
Description: Oxazepam is a short-acting benzodiazepine. It increases neuronal membrane permeability to Cl ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS (including the limbic system, reticular formation) and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.
Pharmacokinetics:
Absorption: Well absorbed from the GI tract. Time to peak plasma concentration: Approx 2-3 hr.
Distribution: It crosses the placenta and detected in breast milk. Plasma protein binding: Approx 97%.
Metabolism: Undergoes hepatic conjugation to produce the major inactive glucuronide metabolite.
Excretion: Via urine as inactive glucuronide conjugate. Elimination half-life: Approx 4-15 hr.
Đặc tính

Chemical Structure Image
Oxazepam

Source: National Center for Biotechnology Information. PubChem Database. Oxazepam, CID=4616, https://pubchem.ncbi.nlm.nih.gov/compound/Oxazepam (accessed on Jan. 22, 2020)

Bảo quản
Store between 15-30°C.
Phân loại MIMS
References
Anon. Oxazepam. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 23/04/2014.

Buckingham R (ed). Oxazepam. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 23/04/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Benzodiazepine General Statement. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 23/04/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Oxazepam. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 23/04/2014.

Oxazepam Capsule (Sandoz Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/04/2014.

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