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Chỉ định và Liều dùng
Oral
Insomnia associated with anxiety Adult: 2.5-5 mg once daily at night. Oral Short-term management of anxiety Adult: 5-20 mg daily in divided doses.
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Renal Impairment
Dose adjustment may be required.
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Hepatic Impairment
Dose adjustment may be required.
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Cách dùng
May be taken with or without food.
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Chống chỉ định
Preexisting CNS depression or coma, resp depression, acute pulmonary insufficiency, myasthenia gravis, sleep apnoea, severe hepatic impairment; not indicated for chronic psychosis, phobic or obsessional states; glaucoma.
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Thận trọng
Chronic pulmonary insufficiency; elderly or debilitated patients; muscle weakness, impaired liver or kidney function; drowsiness may affect skilled tasks; monitor cardio-respiratory function when used for deep sedation; patients with personality disorders or organic brain changes; pregnancy, lactation; history of alcohol or drug addiction, hypotension and apnoea with IV admin, therefore this route should only be used when facilities for reversing resp depression are available. Monitor for signs of suicidal tendency or aggressive behavior; not to be used alone to treat depression or anxiety associated with depression.
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Phản ứng phụ
Drowsiness, sedation, muscle weakness and ataxia; less frequently vertigo, headache, confusion, depression, slurred speech, changes in libido, tremor, visual disturbances, urinary retention, GI disturbances, changes in salivation and amnesia; rarely, jaundice, blood disorders and hypersensitivity reactions; pain and thrombophloebitis; raised liver enzyme values; paradoxical excitation.
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Tương tác
Enhanced sedation or resp and CV depression with drugs with CNS depressant properties e.g. alcohol, antidepressants, antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, opioid analgesics and cisapride.
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Tác dụng
Description: Pinazepam is a long-acting benzodiazepine with general properties similar to diazepam.
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