Potassium iodide

Thông tin thuốc gốc
Chỉ định và Liều dùng
Adult: As potassium iodide saturated solution (SSKI): 300 or 600 mg 3 or 4 times daily.

Radiation protection against radioactive iodine
Adult: 130 mg once daily for 10-14 days, or as directed (depending on the risk of substantial exposure).
Child: ≤1 month 16.25 mg once daily; >1 month to 3 years 32.5 mg once daily; >3-12 years 65 mg once daily; >12 years weighing <68 kg: 65 mg once daily; >12 years weighing ≥68 kg: Same as adult dose.
Chống chỉ định
Nodular thyroid condition with cardiac disease, hypocomplementemic vasculitis, dermatitis herpetiformis.
Thận trọng
Patient with current or history of thyrotoxicosis, nodular goitre or latent Grave’s disease, acute bronchitis, tuberculosis, myotonia congenita, cardiac disease, adrenal insufficiency (e.g. Addison disease), acute dehydration, heat cramp. Renal impairment. Children, especially neonates (in radiation emergency). Treatment with potassium iodide as an expectorant in children should be considered carefully due to potential risks and limited evidence on efficacy. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Hypersensitivity reactions (e.g. angioedema, cutaneous/mucosal haemorrhage); thyroid-related reactions (e.g. hypo- or hyper-thyroidism, thyroid enlargement); iodism or chronic iodine poisoning (prolonged treatment); dermatitis, acne flare-ups.
Cardiac disorders: Cardiac arrhythmia.
Gastrointestinal disorders: Diarrhoea, nausea, vomiting, stomach pain or upset, salivary gland swelling or tenderness, gastrointestinal bleeding.
General disorders and administration site conditions: Fatigue, fever.
Nervous system disorders: Numbness, pain, or tingling sensation in hands or feet.
Psychiatric disorders: Insomnia, confusion, depression, nervousness.
Reproductive system and breast disorders: Impotence.
Skin and subcutaneous tissue disorders: Rash.
Chỉ số theo dõi
Monitor for signs and symptoms of hypo- or hyper-thyroidism; thyroid function tests in pregnant or lactating women and in children ≤3 years if repeat doses are required.
Quá liều
Symptoms: Iodism (e.g. burning mouth or throat, sore teeth or gums, metallic taste, increased salivation, headache, eye irritation, swollen eyelid, nausea, vomiting, diarrhoea, stomach pain, pulmonary oedema and skin lesions); gastrointestinal tract corrosion, renal damage. Management: Maintain airway and stabilise circulation. Give large amount of starch mucilage or milk as antidote. Consider lavage with starch mucilage or activated charcoal if there is no oesophageal damage. Replace electrolyte and water losses. May administer pethidine or morphine sulfate for pain. Perform tracheostomy, if necessary. Haemodialysis may reduce excessively elevated serum iodine concentrations.
Tương tác
Increased risk of hyperkalaemia and cardiac arrhythmia or arrest with K-containing drugs, K-sparing diuretics (e.g. amiloride) and ACE inhibitors (e.g. captopril). Increased risk of thyroid-related reactions with lithium and antithyroid agents.
Ảnh hưởng đến kết quả xét nghiệm
May interfere with thyroid function tests.
Tác dụng
Description: Potassium iodide is an antidote against radioactive iodine, a possible contaminant of the environment, food and water during radiation emergency. It saturates the thyroid gland with non-radioactive iodine thereby preventing uptake of radioactive iodine. It also acts as an expectorant by increasing respiratory tract secretion and decreasing mucous viscosity.
Duration: Radiation protection: Approx 24 hours.
Distribution: Concentrated in the thyroid gland. Crosses the placenta and enters breast milk.
Excretion: Mainly via urine (89%); faeces, saliva, and sweat (small amount).
Đặc tính

Chemical Structure Image
Potassium iodide

Source: National Center for Biotechnology Information. PubChem Database. Potassium iodide, CID=4875, https://pubchem.ncbi.nlm.nih.gov/compound/Potassium-iodide (accessed on Jan. 23, 2020)

Bảo quản
Store between 20-25°C. Protect from light and moisture.
Phân loại MIMS
Thuốc giải độc & khử độc / Thuốc ho & cảm
Phân loại ATC
R05CA02 - potassium iodide ; Belongs to the class of expectorants. Used in the treatment of wet cough.
V03AB21 - potassium iodide ; Belongs to the class of antidotes. Used in the management of radioisotope and heavy metal poisoning.
S01XA04 - potassium iodide ; Belongs to the class of other ophthalmologicals.
Tài liệu tham khảo
Anon. Potassium Iodide. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 08/08/2018 .

Anon. Potassium Iodide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/08/2018 .

Buckingham R (ed). Iodine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/08/2018.

Iostat Tablet (Anbex Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 15/01/2018.

Potassium Iodide 65 mg Tablets (G.L. Pharma GmbH). MHRA. https://products.mhra.gov.uk/. Accessed 04/09/2018.

SSKI Potassium Iodide Solution (Upsher-Smith Laboratories, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/08/2018.

ThyroShield (Fleming & Company, Pharmaceuticals). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/08/2018.

ThySat 65 mg Tablets (Hameln Pharmaceuticals Ltd.). MHRA. https://products.mhra.gov.uk/. Accessed 04/09/2018.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Potassium iodide từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2022 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in