Potassium phosphate


Thông tin kê toa tóm tắt
Chỉ định/Công dụng
Listed in Dosage.
Liều dùng/Hướng dẫn sử dụng
Adult : PO Hypophosphataemia Up to 100 mmol/day of phosphate. Adjunct to urinary antibacterials; Prophylaxis of Ca renal calculi 7.4 mmol of phosphate 4 times/day. IV Severe hypophosphataemia As monobasic potassium phosphate: Up to 10 mmol phosphate over 12 hours and repeated every 12 hours until serum phosphate exceeds 0.3 mmol/L.
Dosage Details
Intravenous
Severe hypophosphataemia
Adult: As monobasic potassium phosphate: Up to 10 mmol phosphate over 12 hours and repeated every 12 hours until serum phosphate exceeds 0.3 mmol/L.
Child: 0.15-0.33 mmol/kg administered over 6 hours. The dose may be repeated at 6 hour-intervals until serum phosphate exceeds 0.6 mmol/L. Rate of infusion should not exceed 0.2 mmol/kg/hour.

Oral
Adjunct to urinary antibacterials, Prophylaxis of calcium renal calculi
Adult: 7.4 mmol of phosphate 4 times daily.

Oral
Hypophosphataemia
Adult: Up to 100 mmol of phosphate daily.
Chống chỉ định
Severe renal impairment, hyperkalaemia, hypocalcaemia, infected phosphate renal calculi.
Thận trọng
Monitor serum electrolyte levels particularly Ca levels, ECG and renal function during the course of therapy esp if K phosphate is administered parenterally. Pregnancy; lactation. Elderly, debilitated patients and those with pre-existing electrolyte disturbances.
Phản ứng phụ
Hyperphosphataemia esp in renal failure which may lead to hypocalcaemia and ectopic calcification esp in hypercalcaemic patients. Hypotension and organ damage due to tissue calcification which may cause acute renal failure. Hyperphosphataemia, hypocalcaemia, tissue calcification; nausea, vomiting, diarrhoea, abdominal pain, flatulence; bradycardia; hyperkalaemia; weakness; dyspnoea.
Potentially Fatal: Acute renal failure, arrhythmia, chest pain, decreased urine output, dyspnoea, oedema, mental confusion, paralysis, paresthesias, phlebitis, tetany (with large doses).
IV/Parenteral/PO: C
Tương tác
Reduced absorption when used with Aluminium, Ca or Mg salts due to binding with the phosphate ion of K phosphate. GI absorption is increased by vit D thus, increasing the risk of hyperphosphataemia. Concomitant admin with drugs increasing serum-potassium concentrations may increase the risk of hyperkalaemia. Increased effect of digitalis may also result to increased digitalis effect.
Lab Interference
Decreases serum ammonia concentration.
Tác dụng
Description: Potassium phosphate is involved in bone deposition, calcium metabolism regulation, acid-base equilibrium buffering and various enzyme systems. It is also vital in maintaining intracellular tonicity, nerve impulse transmission, cardiac contraction, skeletal and smooth muscle, normal renal function maintenance, carbohydrate utilisation, protein synthesis, nerve conduction regulation and muscle contraction esp cardiac muscles.
Pharmacokinetics:
Absorption: Following oral admin, approx 66% is absorbed.
Distribution: Enters the extracellular fluid then actively transported into cells.
Excretion: Via urine, 80-90% of K phosphate; remainder via faeces.
Bảo quản
Store at room temperature.
Phân loại MIMS
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