Thông tin thuốc gốc
Chỉ định và Liều dùng
Benign prostatic hyperplasia, Raynaud's syndrome
Adult: 500 mcg bid for 3-7 days, adjust dose according to response. Max maintenance dose: 2 mg bid.

Heart failure
Adult: Initially, 500 mcg 2-4 times daily, gradually increase according to response. Maintenance: 4-20 mg daily in divided doses.

Adult: Initially, 500 mcg bid or tid for 3-7 days, then increased to 1 mg bid or tid for the next 3-7 days if tolerated, then gradually increase thereafter according to patient's response. Max: 20 mg daily in divided doses.
Renal Impairment
Initially, 500 mcg daily, titrate cautiously.
Hepatic Impairment
Initially, 500 mcg daily, titrate cautiously.
Cách dùng
May be taken with or without food. Starting dose is best taken w/ dinner, at least 2-3 hr before retiring. Maintenance doses may be taken w/ or w/o meals.
Thận trọng
Patient with history of micturition in the treatment of benign prostatic hyperplasia (BPH); CHF due to mechanical obstruction (e.g. aortic valve stenosis, mitral valve stenosis, pulmonary embolism, restrictive pericardial disease). Renal and hepatic impairment. Elderly. Pregnancy and lactation.
Phản ứng phụ
Significant: Angina, CNS depression, floppy iris syndrome, orthostatic hypotension, syncope, loss of consciousness, priapism.
Cardiac disorders: Dyspnoea, palpitations, tachycardia.
Ear and labyrinth disorders: Tinnitus.
Eye disorders: Reddened sclera, blurred vision, eye pain.
Gastrointestinal disorders: Vomiting, diarrhoea, constipation, dry mouth, abdominal pain.
General disorders and administration site conditions: Asthenia.
Metabolism and nutrition disorders: Oedema.
Nervous system disorders: Paraesthesia, vertigo.
Psychiatric disorders: Insomnia, depression, nervousness.
Respiratory, thoracic and mediastinal disorders: Nasal congestion.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Epistaxis, flushing, vasculitis.
Thông tin tư vấn bệnh nhân
This drug may cause dizziness and drowsiness, if affected, do not drive or operate machinery.
Monitoring Parameters
Monitor blood pressure.
Quá liều
Symptoms: Hypotension, profound drowsiness, depressed reflexes. Management: Symptomatic and supportive treatment. Keep patient in supine position to restore blood pressure and normalise heart rate. If inadequate, administer volume expanders in case of shock. Then, administer vasopressors and angiotensin if necessary. Monitor and support renal function as needed.
Tương tác
Additive hypotensive effect with diuretic or other antihypertensive agent (e.g. β-adrenergic blockers). May cause symptomatic hypotension with phosphodiesterase type 5 (PDE5) inhibitors (e.g. sildenafil).
Lab Interference
May give false positive results in screening tests for phaeochromocytoma urinary vanillylmandelic acid (VMA) and methoxyhydroxyphenyl glycol (MHPG) metabolites for norepinephrine.
Tác dụng
Description: Prazosin is an alpha blocker that competitively inhibits postsynaptic alpha1-adrenoreceptors in vascular smooth muscles, resulting to vasodilation, and decrease in total peripheral resistance and blood pressure.
Onset: Within 2 hours.
Duration: 10-24 hours.
Absorption: Readily absorbed from gastrointestinal tract. Bioavailability: 43-82%. Time to peak plasma concentration: 1-3 hours.
Distribution: Enters breast milk (small amounts). Volume of distribution: 0.5 L/kg. Plasma protein binding: 97%.
Metabolism: Extensively metabolised in the liver via demethylation and conjugation.
Excretion: Mainly via faeces (5-11% as unchanged drug); urine (<10%). Half-life: Approx 2-3 hours; 7 hours (patients with CHF).
Đặc tính

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Prazosin, CID=4893, (accessed on Jan. 23, 2020)

Bảo quản
Store below 30°C.
Phân loại MIMS
Phân loại ATC
C02CA01 - prazosin ; Belongs to the class of alpha-adrenoreceptor antagonists, peripherally-acting antiadrenergic agents. Used in the treatment of hypertension.
Anon. Prazosin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 29/03/2019.

Buckingham R (ed). Prazosin Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 29/03/2019.

Joint Formulary Committee. Prazosin. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 29/03/2019.

Prazosin Hydrochloride Capsule (Greens Tone LLC). DailyMed. Source: U.S. National Library of Medicine. Accessed 29/03/2019.

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