Acute migraine attacks
Adult: 5 or 10 mg as soon as possible after onset, repeat after 2 hours if significant relief is not attained. Max: 20-30 mg per 24 hours.
Chỉ định và Liều dùng
Oral
Acute migraine attacks Adult: 5 or 10 mg as soon as possible after onset, repeat after 2 hours if significant relief is not attained. Max: 20-30 mg per 24 hours.
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Special Patient Group
Patients taking concomitant propranolol: Initiate with 5 mg. Max: 10-15 mg daily. Ensure that the 2 drugs are separated by at least 2 hours interval.
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Renal Impairment
For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hr. Max: 10 mg/24 hr. Avoid in severe impairment.
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Hepatic Impairment
For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hr. Max: 10 mg/24 hr. Avoid in severe impairment.
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Cách dùng
Tab: May be taken with or without food.
Orally-Disintegrating Tab: May be taken with or without food. Place on the tongue & allow to dissolve; it can then be swallowed w/ the saliva. |
Chống chỉ định
History of MI, peripheral vascular disease, transient ishaemic attack, ischaemic heart disease or Prinzmetal's angina; uncontrolled hypertension; basilar or hemiplegic migraine; severe hepatic or renal impairment. Adolescent <18 yr.
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Thận trọng
Elderly; mild to moderate hepatic or renal impairment; coronary artery disease; pregnancy, lactation. May cause drowsiness. History of seizures. Ensure an interval of at least 24 hr after stopping an ergotamine compound and starting a serotonin (5-HT1) agonist.
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Phản ứng phụ
Increased BP, chest pain, palpitation; skin flushing; dyspnoea; nausea, abdominal pain, dry mouth; dizziness, drowsiness, fatigue.
Potentially Fatal: Toxic epidermal necrolysis. |
Quá liều
May cause hypertension and CV symptoms. Gastric lavage using activated charcoal may be considered. Monitor ECG and clinical status of the patient.
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Tương tác
Increased serum concentrations with propranolol. Increased risk of vasospastic reactions when used with ergotamine and methysergide. Concurrent use with SSRIs may increase risk of serotonin syndrome.
Potentially Fatal: Concurrent use with or within 2 wk of stopping MAOI treatment. |
Food Interaction
Absorption delayed. Concurrent use with St John's wort may increase risk of adverse reactions.
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Tác dụng
Description: Rizatriptan is a selective serotonin (5-HT1) agonist in cranial arteries responsible for vasoconstriction and reduction of inflammation associated with antidromic neuronal transmission.
Pharmacokinetics: Absorption: Bioavailability: about 40-45%. Distribution: Protein binding: 14%. Metabolism: Primarily by monoamine oxidase type A. Excretion: About 14% of an oral dose is excreted unchanged in the urine. Plasma half-life: about 2-3 hr. |
Bảo quản
Store at 15-30°C.
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Phân loại MIMS
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