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Chỉ định và Liều dùng
Oral
Fever, Osteoarthritis, Pain, Rheumatoid arthritis Adult: Up to 3 g daily in divided doses.
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Cách dùng
Should be taken with food. Take w/ food or milk.
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Chống chỉ định
Haemophilia, haemorrhagic disorders, gout, hypersensitivity to aspirin or NSAIDs. Children <12 yr. Pregnancy (3rd trimester) and lactation. Severe renal or hepatic impairment.
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Thận trọng
Peptic ulcers; asthma, allergic disorders. Impaired hepatic or renal function. Dehydrated patients; uncontrolled hypertension. May cause acute haemolytic anaemia in patients with G6PD deficiency.
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Tác dụng không mong muốn
GI symptoms, hypersensitivity reactions, skin eruptions, angioedema, weakness, rhinitis and dyspnoea, hypoprothrombinaemia. Hepatotoxicity, renal impairment, iron-deficiency anaemia, occult bleeding. Local irritation (rectally); Reye's syndrome.
Potentially Fatal: Paroxysmal bronchospasm, thrombocytopenia, leukopenia. |
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PO: C, Z (NSAIDs caused foetal ductus arteriosus premature closure, foetal renal impairment and persistent pulmonary hypertension. Avoid near term, else use lowest dose for shortest time.)
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Tương tác
May increase risk of liver damage when used with gold compounds. GI effects may be enhanced with alcohol or concurrent use with corticosteroids. May increase activity of coumarin anticoagulants, sulfonylureas, zafirlukast, methotrexate, phenytoin and valproate. May decrease the activity of probenecid and sulfinpyrazone.
Potentially Fatal: Increased risk of adverse effects when used with other NSAIDs. |
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Ảnh hưởng đến kết quả xét nghiệm
Glucose oxidase urinary glucose tests: False-negative results. Cupric sulfate method: False-positive. Interferes with Gerhardt test, vanillyl mandelic acid (VMA) determination; 5-hydroxy indole acetic acid (5-HIAA), xylose tolerance test and T3 and T4.
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Tác dụng
Description: Salsalate is a non-acetylated salicylic acid derivative with analgesic, anti-inflammatory and antipyretic actions similar to those of aspirin. It inhibits prostaglandin synthesis, acts on the hypothalamus heat-regulating center to reduce fever, blocks prostaglandin synthetase thus preventing thromboxane A2 formation.
Onset: Therapeutic: 3-4 days (continuous dosing). Pharmacokinetics: Absorption: Each molecule of salsalate is hydrolysed in the small intestines to 2 molecules of salicylic acid. Excretion: About 13% of salsalate is excreted as glucuronide conjugates in the urine. |
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Phân loại MIMS
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