Secnidazole


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Intestinal amoebiasis
Adult: As tab: 2 g as single dose. Treatment recommendations may vary among countries and available products. Consider local treatment or detailed product guidelines on the appropriate use or recommendations.
Child: As tab: 30 mg/kg as single dose.

Oral
Hepatic amoebiasis
Adult: As tab: 1.5 g daily as single or in divided doses for 5 days. Treatment recommendations may vary among countries and available products. Consider local treatment or detailed product guidelines on the appropriate use or recommendations.
Child: As tab: 30 mg/kg daily as single or in divided doses for 5 days.

Oral
Bacterial vaginosis
Adult: As granules or tab: 2 g as single dose. Treatment recommendations may vary among countries and available products. Consider local treatment or detailed product guidelines on the appropriate use or recommendations.

Oral
Trichomoniasis
Adult: As tab: 2 g as single dose. Treatment recommendations may vary among countries and available products. Consider local treatment or detailed product guidelines on the appropriate use or recommendations.

Oral
Giardiasis
Child: As tab: 30 mg/kg as single dose. Treatment recommendations may vary among countries and available products. Consider local treatment or detailed product guidelines on the appropriate use or recommendations.
Hướng dẫn pha thuốc
Granules: Sprinkle contents onto applesauce, yoghurt, or pudding.
Chống chỉ định
Hypersensitivity to secnidazole or other nitroimidazole derivatives. Lactation.
Thận trọng
Children. Pregnancy. Avoid chronic use. Granules are not intended to be dissolved or administered in any liquid.
Tác dụng không mong muốn
Significant: Vulvovaginal candidiasis.
Blood and lymphatic system disorders: Moderate leucopenia.
Gastrointestinal disorders: Nausea, diarrhoea, abdominal pain, dysgeusia, vomiting, stomatitis, glossitis.
Nervous system disorders: Headache.
Reproductive system and breast disorders: Vulvovaginal pruritus.
Skin and subcutaneous tissue disorders: Urticaria.
Chỉ số theo dõi
For bacterial vaginosis: Perform culture and susceptibility tests; consult local institutional recommendations before treatment initiation due to antibacterial resistance risks.
Tương tác
May increase the effects of oral anticoagulant drugs thus increase the risk of bleeding.
Tác dụng
Description: Secnidazole, a 5-nitroimidazole derivative, is an antiprotozoal and antibacterial agent. Its mechanism of action is not fully elucidated, but it is believed to be activated following its entry as inactive prodrug into the microorganisms, where it is reduced by low oxidation-reduction potential ferredoxin, thus resulting in DNA damage.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: 4 hours (range: 3-4 hours).
Distribution: Volume of distribution: Approx 42 L. Plasma protein binding: <5%.
Metabolism: Metabolised in the liver via oxidation by the CYP450 enzyme system into metabolites.
Excretion: Via urine (approx 15% as unchanged drug). Elimination half-life: Approx 17 hours.
Đặc tính

Chemical Structure Image
Secnidazole

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 71815, Secnidazole. https://pubchem.ncbi.nlm.nih.gov/compound/Secnidazole. Accessed Apr. 26, 2021.

Bảo quản
Store between 15-30°C.
Phân loại MIMS
Thuốc diệt amib / Các loại kháng sinh khác / Thuốc khác trị bệnh do động vật nguyên sinh
Phân loại ATC
P01AB07 - secnidazole ; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases.
Tài liệu tham khảo
Anon. Secnidazole. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 05/04/2021.

Anon. Secnidazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/04/2021.

Buckingham R (ed). Secnidazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/04/2021.

Solosec (Lupin Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 05/04/2021.

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