|
Chỉ định và Liều dùng
Oral
Constipation Adult: 15-30 mg (as total sennosides) 1-2 times daily. Child: 2-6 yr: 3.75-7.5 mg once daily in the morning; 6-12 yr: 7.5-15 mg once daily at night or in the morning; ≥12 yr: 15-30 mg at bedtime. Oral Bowel evacuation Adult: 105-157.5 mg of sennosides on the day before the procedure. May be given as a liquid preparation.
|
|
Chống chỉ định
Nausea or vomiting, undiagnosed abdominal pain, intestinal obstruction.
|
|
Thận trọng
Inflammatory bowel disease. Avoid prolonged use.
|
|
Phản ứng phụ
Mild abdominal discomfort e.g. colic and cramps; diarrhoea, hypokalaemia and atonic non-functioning colon (prolonged use); reversible melanosis coli (chronic use). May colour the urine yellowish-brown at acidic pH or red at alkaline pH.
|
|
Tác dụng
Description: Sennosides A and B increase intestinal motility through release of active anthraquinones into the colon by colonic bacteria. Purified sennosides (sennosides A and B) are used similarly to senna.
Duration: 6-12 hr. Pharmacokinetics: Absorption: Some absorption following oral admin. Distribution: Enters the breast milk. Metabolism: Unabsorbed senna undergoes hydrolysis in the colon to release the active anthraquinones while absorbed senna undergoes hepatic metabolism. Excretion: Excreted in the urine & faeces. |
|
Phân loại MIMS
|
Manage Account
Change Password
Sign Out
