Children with short stature homeobox-containing (SHOX) deficiency
Child: 50 mcg/kg/day may be used.
Subcutaneous
Growth retardation due to chronic renal insufficiency, Turner's syndrome
Child: 45-50 mcg/kg or 1.4 mg/m2 daily.
Subcutaneous
Growth retardation in children who were born small for gestational age, Prader-Will syndrome
Child: 35 mcg/kg or 1 mg/m2 daily. Max: 2.7 mg daily.
Subcutaneous
Growth hormone deficiency
Adult: Initially, 6 mcg/kg daily. May increase gradually according to patient response. Max: 12.5 mcg/kg/day. Reassess 9 mth after starting treatment.
Child: 25-35 mcg/kg daily. Reassess 9 mth after starting treatment.
Elderly: Lower doses may be required.
Child: 25-35 mcg/kg daily. Reassess 9 mth after starting treatment.
Elderly: Lower doses may be required.
Subcutaneous
Short bowel syndrome
Adult: 100 mcg/kg/day for 4 wk. Max: 8 mg/day.
Subcutaneous
HIV-associated wasting or cachexia
Adult: 0.1 mg/kg daily at bedtime. May be taken on alternate days for patients at increased risk of adverse effects. Max: 6 mg/day.