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Chỉ định và Liều dùng
Oral
Peptic ulcer Adult: 1 g 4 times daily or 2 g bid for 4-8 wk, may extend up to 12 wk if necessary. Maintenance dose to prevent the recurrence of duodenal ulcers: 1 g bid. Max: 8 g daily. Oral Chronic gastritis Adult: 1 g 4 times daily or 2 g bid for 4-8 wk, may extend up to 12 wk if necessary. Max: 8 g daily. Oral Prophylaxis of gastrointestinal haemorrhage from stress ulceration Adult: 1 g 6 times daily. Max: 8 g daily.
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Cách dùng
Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.
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Thận trọng
Patient w/ known conditions that may impair swallowing (e.g. recent or prolonged intubation, tracheostomy, dysphagia). Renal impairment. Pregnancy and lactation.
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Phản ứng phụ
Nervous: Headache, dizziness, drowsiness, insomnia, vertigo.
GI: Constipation, diarrhoea, nausea, vomiting, flatulence, indigestion, gastric discomfort, dry mouth. Musculoskeletal: Back pain. Dermatologic: Pruritus, skin rash. |
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Tương tác
May increase total body burden of Al w/ drugs that contain Al (e.g. Al-containing antacids). May reduce absorption of tetracyclines, ranitidine, ketoconazole, theophylline, phenytoin, cimetidine, ciprofloxacin, norfloxacin and digoxin.
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Tác dụng
Description: Sucralfate protects GI lining against peptic acid, pepsin and bile salts by binding w/ positively-charged proteins in exudates forming a viscous paste-like adhesive substance thus forming a protective coating.
Onset: 1-2 hr. Duration: 6 hr. Pharmacokinetics: Absorption: Minimally absorbed from the GI tract. Distribution: Acts locally at ulcer sites; unbound in GI tract to aluminum and sucrose octasulfate. Excretion: Mainly via urine. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Sucralfate, CID=121494085, https://pubchem.ncbi.nlm.nih.gov/compound/Sucralfate (accessed on Jan. 31, 2020) |
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Bảo quản
Store between 20-25°C.
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Phân loại MIMS
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Phân loại ATC
A02BX02 - sucralfate ; Belongs to the class of other drugs used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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References
Anon. Sucralfate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 18/10/2017. Buckingham R (ed). Sucralfate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/10/2017. Joint Formulary Committee. Sucralfate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/10/2017. McEvoy GK, Snow EK, Miller J et al (eds). Sucralfate. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 18/10/2017. Sucralfate Tablet (Actavis Pharma, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 18/10/2017.
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