Tazarotene


Thông tin thuốc gốc
Chỉ định và Liều dùng
Topical/Cutaneous
Photoaging
Adult: >17 yr As 0.1% cream: Apply a pea-sized amount to lightly cover the entire face (may include the eyelids) once daily at bedtime.

Topical/Cutaneous
Mild to moderate plaque psoriasis
Adult: >18 yr As 0.05 or 0.1% cream/gel: Apply a thin layer to the affected lesion(s) once daily in the evening. Initiate at a strength of 0.05% then increase to 0.1% as tolerated. If drying or irritation occurs, apply a moisturiser at least 1 hr before admin of tazarotene. Usual duration of therapy: 12 wk (up to 12 mth if necessary).

Topical/Cutaneous
Acne vulgaris
Adult: As 0.1% cream/foam: Apply a thin layer to cover the entire affected area(s) once daily in the evening. May use moisturiser as needed. Usual duration of therapy: 12 wk.
Child: ≥12 yr Same as adult dose.
Chống chỉ định
Patient w/ eczema and sunburn. Application to psoriatic lesions >10-20% of BSA. Pregnancy and lactation.
Thận trọng
Patient w/ history of skin cancer.
Phản ứng phụ
Significant: Desquamation, pruritus, skin redness, stinging/burning sensation, worsening of psoriasis, swelling at/near application sites, skin discoloration (hyper/hypopigmentation), skin exfoliation and inflammation, hypersensitivity (e.g. urticaria), photosensitivity.
CV: Peripheral oedema.
Endocrine: Hypertriglyceridaemia.
Dermatologic: Erythema, irritation, dermatitis, rash.
Thông tin tư vấn bệnh nhân
Do not use occlusive dressings. Avoid contact w/ inflamed skin, intertriginous areas, hair-covered scalp, eyes, mouth, and other mucous membranes. Avoid exposure to sunlight or other UV rays.
MonitoringParameters
Perform pregnancy test w/in 2 wk prior to initiation of therapy and start treatment during a menstrual period.
Tương tác
Increased photosensitivity w/ drugs known to be photosensitisers (e.g. fluoroquinolones, tetracyclines, thiazide diuretics, sulfonamides, phenothiazines). Increased risk of irritation w/ use of topical medications and cosmetics w/ irritant or strong drying effects.
Tác dụng
Description: Tazarotene, a synthetic acetylenic retinoid, is a prodrug which is converted to tazarotenic acid then binds to 3 retinoic acid receptors but has relative selectivity for RARβ and RARγ. It regulates gene expression, thus modulating cell proliferation, differentiation, and hyperplasia.
Pharmacokinetics:
Distribution: Plasma protein binding: highly bound as tazarotenic acid (>99%).
Metabolism: Metabolised via esterase hydrolysis to tazarotenic acid and via oxidation to inactive sulfoxides, sulfones, and other polar metabolites.
Excretion: Via urine and faeces. Elimination half-life: Approx 18 hr.
Đặc tính

Chemical Structure Image
Tazarotene

Source: National Center for Biotechnology Information. PubChem Database. Tazarotene, CID=5381, https://pubchem.ncbi.nlm.nih.gov/compound/Tazarotene (accessed on Jan. 23, 2020)

Bảo quản
Store between 20-25°C. Do not freeze. Protect from heat.
Phân loại ATC
D05AX05 - tazarotene ; Belongs to the class of other antipsoriatics for topical use.
References
Avage Cream (Allergan, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 13/11/2017.

Buckingham R (ed). Tazarotene. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/11/2017.

Fabior Aerosol (Mayne Pharma LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/11/2017.

Joint Formulary Committee. Tazarotene. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/11/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Tazarotene (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 10/11/2017.

Tazorac Cream (Allergan, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/11/2017.

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