Thông tin thuốc gốc
Chỉ định và Liều dùng
Acute musculoskeletal disorders, Osteoarthritis, Rheumatoid arthritis
Adult: 20 mg as a single dose, taken at the same time each day. Treatment duration: Up to 7 days for acute musculoskeletal disorders and up to 14 days for severe cases.
Elderly: Use the lowest effective dose for the shortest possible duration.

Acute musculoskeletal disorders, Osteoarthritis, Rheumatoid arthritis
Adult: Initially, 20 mg IM/IV as a single dose given for 1-2 days, to be continued w/ the oral form, administered at the same time each day. Treatment duration: Up to 7 days for acute musculoskeletal disorders and up to 14 days for severe cases.
Elderly: Use the lowest effective dose for the shortest duration.
Cách dùng
Should be taken with food. Take w/ or immediately after meals.
Hướng dẫn pha thuốc
Dissolve lyophilisate in 2 mL of sterile water for inj.
Chống chỉ định
Hypersensitivity to tenoxicam, aspirin or other NSAIDs. History of or active peptic ulceration, GI bleeding (melaena, haematemesis) or severe gastritis; severe heart failure. Last trimester of pregnancy.
Thận trọng
Patient w/ history of or active bronchial asthma, uncontrolled HTN, CHF, established ischaemic heart disease, peripheral arterial disease, cerebrovascular disease, risk factors for CV disease (e.g. HTN, hyperlipidaemia, DM, smoking), history of GI disease, fluid retention and oedema. Patient who will undergo major surgery (e.g. joint replacement). Elderly. Renal and hepatic impairment.
Phản ứng phụ
Dyspepsia, nausea, abdominal pain and discomfort, constipation, diarrhoea, flatulence, indigestion, epigastric distress, stomatitits, anorexia; peripheral oedema; headache, dizziness; allergic reactions, asthma, bronchospasm, dyspnoea, rash, pruritus; decreased Hb, anaemia, thrombocytopenia, non-thrombocytopenic purpura, leucopenia, eosinophilia, epistaxis; increased serum transaminase levels; swollen eyes, blurred vision, eye irritation, malaise, tinnitus; oedema, HTN, cardiac failure.
Potentially Fatal: Peptic ulceration, GI bleeding, anaphylaxis, Lyell's syndrome, Stevens-Johnson syndrome, exfoliative dermatitis, nephrotoxicity, arterial thrombotic events (e.g. MI or stroke), hepatitis, jaundice.
Parenteral/PO: Z (NSAIDs use in >20 weeks gestation may cause oligohydramnios and fetal renal impairment. Fetal ductus arteriosus premature closure and persistent pulmonary hypertension may occur >30 weeks gestation. Avoid NSAIDs 30 weeks and later. If a NSAID is needed during 20-30 weeks, use lowest effective dose for shortest duration.)
Monitor renal, hepatic and cardiac functions.
Quá liều
Symptoms: Headache, nausea, vomiting, epigastric pain, GI bleeding, rarely diarrhoea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, fainting, occasionally convulsions. Acute renal failure and liver damage may occur. Management: Symptomatic treatment. Ensure good urine output. Frequent or prolonged convulsions should be treated w/ IV diazepam. May administer an H2-antagonist.
Tương tác
Increased risk of adverse effects (particularly GI) w/ salicylates and other NSAIDs. May enhance the anticoagulant effect of warfarin and other anticoagulants. May reduce the effect of antihypertensive drugs. Increased risk of nephrotoxicity w/ ciclosporin. Increased risk of convulsions w/ quinolones. May decrease the elimination of lithium. May interfere w/ the natriuretic action of diuretics. May enhance the toxicity of methotrexate. May reduce the effects of mifepristone. Increased risk of GI bleeding w/ corticosteroids.
Food Interaction
Food may delay the rate of absorption.
Tác dụng
Description: Tenoxicam is an NSAID which has marked anti-inflammatory and analgesic activity and some antipyretic activity. As w/ other NSAIDs, the precise mode of action is unknown, though it is probably multifactorial, involving inhibition of prostaglandin biosynthesis and reduction of leucocyte accumulation at the inflammatory site.
Absorption: Well absorbed from the GI tract. Rapidly absorbed after IM inj. Food may delay the rate (to approx 6 hr) of absorption. Time to peak plasma concentration: Approx 2 hr.
Distribution: Penetrates synovial fluid. Plasma protein binding: Approx 99%.
Metabolism: Completely metabolised to inactive metabolites.
Excretion: Mainly via urine, some via bile as glucoronide conjugates of the metabolites. Plasma elimination half-life: 42-81 hr.
Đặc tính

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Tenoxicam, CID=54677971, https://pubchem.ncbi.nlm.nih.gov/compound/Tenoxicam (accessed on Jan. 23, 2020)

Bảo quản
Store below 30°C.
Anon. Tenoxicam. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/11/2014.

Buckingham R (ed). Tenoxicam. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/11/204.

Tenoxicam 20 mg Lyophilisate for Solution for Injection (Chemidex Pharma Ltd). MHRA. https://products.mhra.gov.uk/. Accessed 21/11/2014.

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