Tetracosactide


Thông tin thuốc gốc
Chỉ định và Liều dùng
Intramuscular
Crohn's disease, Rheumatoid arthritis
Adult: Alternative to corticosteroids for short-term therapy of cases in patients who are intolerant to oral glucocorticoids: As long-acting depot: Initially, 1 mg daily, or 1 mg 12 hourly (in acute cases). Once acute symptoms are controlled or adequate response is achieved, may continue treatment at reduced doses of 0.5-1 mg every 2-3 days or 1 mg once weekly.
Child: As long-acting depot: 3-<5 years Initially, 0.25-0.5 mg daily. Maintenance: 0.25-0.5 mg every 2-8 days; 5-12 years Initially, 0.25-1 mg daily. Maintenance: 0.25-1 mg every 2-8 days.

Parenteral
Diagnostic test for investigation of adrenocortical insufficiency
Adult: 30-minute diagnostic test: As conventional preparation: 0.25 mg as a single dose via IV inj over 2 minutes or IM inj, with plasma-cortisol levels measured immediately before and exactly 30 minutes after the inj. If there is a post-inj rise in plasma cortisol levels of at least 200 nmol/L (70 mcg/L), the adrenocortical function may be regarded as normal. Doses may be given via IV infusion over 6 hours when greater cortisol stimulation is necessary. 5-hour diagnostic test: As long-acting depot (if inconclusive results with conventional preparation or to determine adrenal cortex functional reserve): 1 mg as a single IM inj dose, with plasma cortisol levels measured immediately before and exactly 0.5, 1, 2, 3, 4, and 5 hours after the inj. If post-inj rise in plasma cortisol levels doubles in the 1st hour then continues to rise steadily, the adrenocortical function is normal. For the differentiation between primary and secondary adrenocortical insufficiency, the depot preparation may be used as a 3-day test. Refer to detailed product guideline for further instructions on testing.
Child: 30-minute diagnostic test: As conventional preparation: Max: 0.25 mg/1.73 m2 as a single dose via IV inj over 2 minutes. Consider detailed product or local guidelines for specific dosage requirements.
Special Patient Group
Patient undergoing therapy for diabetes mellitus or hypertension: Long-acting depot: Dosage adjustments may be required.
Hướng dẫn pha thuốc
IV/IM Powder for inj (for diagnostic use): IM: Reconstitute vial labelled as 0.25 mg with 1 mL of 0.9% NaCl. IV inj: Further dilute the reconstituted solution for IM inj in 0.9% NaCl to a total volume of 2-5 mL. IV infusion: Mix 0.25 mg dose in 0.9% NaCl or 5% dextrose in water.
Chống chỉ định
Allergic disorders (e.g. asthma), untreated infection, acute psychosis, peptic ulcer, refractory heart failure, Cushing’s syndrome; treatment of primary adrenocortical insufficiency and adrenocongenital syndrome.
Thận trọng
Patient with active infectious or systemic disease; latent TB or amoebiasis, reduced immune response, hypertension, thromboembolic tendencies, ocular herpes simplex, cataracts, glaucoma, diabetes mellitus, gastrointestinal disease (e.g. nonspecific ulcerative colitis, recent intestinal anastomosis, diverticulitis), osteoporosis, myasthenia gravis, liver cirrhosis, hypothyroidism. Patient with critical illness, nephrotic syndrome, those receiving oral contraceptives, hydrocortisone, cortisone or spironolactone, or have previously undergone operation may have an inaccurate result of plasma cortisol levels; use alternative parameters for assessment. Patient subjected to stress conditions (e.g. trauma, surgery, illness). Concomitant administration with live vaccines. Renal and hepatic impairment. Children. Pregnancy and lactation.
Phản ứng phụ
Significant: Hypersensitivity reactions (e.g. marked redness and pain at the inj site, urticaria, pruritus, severe malaise or dyspnoea, flushing), psychological disturbances (e.g. euphoria, insomnia, mood swings, personality changes, severe depression, frank psychotic manifestations); increased intraocular pressure, ocular effects with prolonged use (e.g. corneal perforation, glaucoma, cataracts); salt and water retention, activation of latent TB or amoebiasis.
Cardiac disorders: Bradycardia, tachycardia.
Ear and labyrinth disorders: Vertigo.
Endocrine disorders: Adrenal haemorrhage, Cushing’s syndrome, secondary adrenocortical and pituitary unresponsiveness (particularly during stress); growth retardation in children.
Gastrointestinal disorders: Pancreatitis, peptic ulcer with perforation and haemorrhage, oesophagitis ulcerative, abdominal distension.
General disorders and administration site conditions: Impaired healing.
Infections and infestations: Abscess.
Immune system disorders: Increased infection susceptibility.
Investigations: Increased weight.
Metabolism and nutrition disorders: Latent diabetes mellitus, decreased carbohydrate tolerance, hyperglycaemia, hypokalaemia, Ca deficiency, increased appetite, hypokalaemic alkalosis, peripheral oedema.
Musculoskeletal and connective tissue disorders: Osteoporosis, myopathy, pathological fracture of long bones.
Nervous system disorders: Convulsion, headache.
Reproductive system and breast disorders: Irregular menstruation.
Skin and subcutaneous tissue disorders: Hirsutism, rash, skin atrophy.
Vascular disorders: Hypertension, necrotising vasculitis, thromboembolism.
IM/IV/Parenteral: C
MonitoringParameters
Monitor for signs or symptoms of hypersensitivity approx 1 hour after administration. For the diagnosis of adrenocortical insufficiency: Assess plasma cortisol prior to and 4-6 hours after inj. For therapeutic (prolonged) use: Monitor blood pressure, weight, urinalysis, glucose, electrolytes; signs and symptoms of infection, cataract, intraocular pressure, bone mass density, growth and ECG in children. May consider routine eye exam.
Quá liều
Symptoms: Fluid retention, Cushing’s syndrome. Management: Symptomatic treatment. May temporarily withdraw, give in lower doses, or prolong the interval between injections of tetracosactide.
Tương tác
May enhance the hepatotoxic effects of valproate (particularly in children), phenytoin, clonazepam, nitrazepam, phenobarbital, primidone. Increased total cortisol levels with synthetic estrogens thus may diminish the diagnostic effect of tetracosactide. May potentiate the electrolyte loss with diuretics.
Lab Interference
May suppress reactions to skin tests.
Tác dụng
Description: Tetracosactide is a synthetic polypeptide that stimulates the adrenal cortex to secrete adrenal steroids (including hydrocortisone, cortisone), androgenic substances, and to a lesser extent, aldosterone.
Synonyms: tetracosactrin, cosyntropin.
Onset: Increased plasma cortisol concentrations: Within 5 minutes.
Duration: 12 hours (IM).
Pharmacokinetics:
Absorption: Time to peak plasma concentration: Approx 1 hour.
Distribution: Rapidly distributed particularly in the adrenals and kidneys. Volume of distribution: Approx 0.4 L/kg.
Metabolism: Metabolised by serum endopeptidases into inactive oligopeptides, then by aminopeptidases into free amino acids.
Excretion: IV: Via urine (95-100%). Elimination half-life: 3 phases: Approx 7 minutes (range: approx 0-1 hour), 37 minutes (range: 1-2 hours), 3 hours.
Đặc tính

Chemical Structure Image
Tetracosactide

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 16133802, Tetracosactide acetate. https://pubchem.ncbi.nlm.nih.gov/compound/Tetracosactide-acetate. Accessed Oct. 27, 2020.

Bảo quản
Powder for inj: Store between 20-25°C. Solution/suspension for inj: Store between 2-8°C. Protect from light.
Phân loại MIMS
Phân loại ATC
H01AA02 - tetracosactide ; Belongs to the class of ACTH. Used in anterior pituitary lobe hormone and analogue preparations.
References
Anon. Cosyntropin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/08/2020.

Buckingham R (ed). Tetracosactide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/08/2020.

Cortrosyn Injection, Powder, Lyophilized, for Solution (General Injectables & Vaccines, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/08/2020.

Joint Formulary Committee. Tetracosactide. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/08/2020.

Juno Pharmaceuticals NZ Pty Ltd. Synacthen Depot IM Suspension for Injection data sheet 23 April 2018. Medsafe. http://www.medsafe.govt.nz/. Accessed 10/08/2020.

Synacthen Ampoules 250 mcg (Atnahs Pharma UK Limited). MHRA. https://products.mhra.gov.uk/. Accessed 10/08/2020.

Synacthen Depot Ampoules 1 mg/1 mL (Mallinckrodt Specialty Pharmaceuticals Ireland Ltd). MHRA. https://products.mhra.gov.uk/. Accessed 10/08/2020.

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