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Chỉ định và Liều dùng
Oral
Prophylaxis of thromboembolic disorder Adult: Usual dose: 300-900 mg daily.
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Cách dùng
Should be taken with food.
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Phản ứng phụ
Nausea, vomiting, gastric and epigastric pain, erythema, conjunctival haemorrhage, epistaxis.
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Tác dụng
Description: Triflusal, a derivative of salicylic acid, is an inhibitor of platelet aggregation. It inhibits platelet arachidonic metabolism and stimulates platelet cAMP production. Unlike aspirin, it does not increase bleeding time. It may also have neuroprotective effects as animal studies have shown that it blocks the biochemical pathway that leads to cell damage during ischemia in the nervous system.
Pharmacokinetics: Absorption: Bioavailability: 83-100%. Peak plasma concentration: 0.88 hr (triflusal); 4.96 hr (HTB). Distribution: Protein binding: extensive. Metabolism: Rapidly metabolised by liver to active metabolite, 3-Hydroxy-4-trifluoro-methylbenzoic acid (HTB). Excretion: Via urine as metabolites. Terminal half life: 0.53 hr (triflusal); 34.29 hr (HTB) |
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