Tropicamide


Thông tin thuốc gốc
Chỉ định và Liều dùng
Ophthalmic
Production of cycloplegia
Adult: For refraction: As 1% solution: Instil 1 or 2 drops into the eye(s); repeat after 5 minutes. An additional drop may be administered if the patient is not examined within 20-30 minutes. Additional doses may be required in patients with heavily pigmented eyes.

Ophthalmic
Production of mydriasis
Adult: For funduscopic examination: As 0.5% solution: Instil 1 or 2 drops into the eye(s) 15-20 minutes before examination. Higher strength or additional doses may be required in patients with heavily pigmented eyes.
Chống chỉ định
Known or suspected angle-closure glaucoma, narrow anterior chamber angle.
Thận trọng
Patient with inflamed eye(s), increased intraocular pressure; hypersensitivity to belladonna alkaloids or other anticholinergic drugs. Pregnancy and lactation.
Phản ứng phụ
Significant: Transient increase in intraocular pressure, CNS disturbances.
Cardiac disorders: Tachycardia, bradycardia, palpitations, arrhythmia.
Eye disorders: Blurred vision, photophobia, eye pain or irritation, superficial punctate keratitis, transient stinging, ocular hyperaemia.
Gastrointestinal disorders: Dry mouth, nausea, vomiting, reduced gastrointestinal motility, constipation.
General disorders and administration site conditions: Prolonged mydriatic effect.
Immune system disorders: Allergic reactions.
Musculoskeletal and connective tissue disorders: Muscle rigidity.
Nervous system disorders: Dizziness, headache.
Renal and urinary disorders: Urinary urgency, difficulty, and retention.
Skin and subcutaneous tissue disorders: Rash, dry skin.
Vascular disorders: Hypotension, syncope, flushing, pallor.
Thông tin tư vấn bệnh nhân
Remove contact lenses before application and wait for at least 15 minutes before reinsertion. This drug may cause drowsiness, blurred vision and sensitivity to light, if affected, do not drive or operate machinery.
MonitoringParameters
Determine intraocular pressure and estimate the depth of the angle of the anterior chamber before initiation of therapy.
Tương tác
May interfere with the ocular antihypertensive effects of pilocarpine, carbachol or ophthalmic cholinesterase inhibitors. Effects may be enhanced when used concomitantly with other drugs having antimuscarinic properties (e.g. amantadine, certain antihistamines, antipsychotics, TCAs).
Tác dụng
Description: Tropicamide is a synthetic tertiary amine antimuscarinic which blocks the responses of the sphincter muscle of the iris and ciliary muscle to cholinergic stimulation resulting in pupillary dilation. It also causes paralysis of accommodation at higher concentrations.
Onset: Mydriasis: Approx 20-40 minutes. Cycloplegia: 20-35 minutes (peak).
Duration: Mydriasis: Approx 6-7 hours. Cycloplegia: 50 minutes to 6 hours.
Đặc tính

Chemical Structure Image
Tropicamide

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 5593, Tropicamide. https://pubchem.ncbi.nlm.nih.gov/compound/Tropicamide. Accessed Jan. 25, 2021.

Bảo quản
Store between 8-27°C. Do not refrigerate or freeze. Protect from light. Storage recommendations may vary among countries or individual products. Refer to specific product guidelines.
Phân loại MIMS
Phân loại ATC
S01FA06 - tropicamide ; Belongs to the class of anticholinergics used as mydriatics and cycloplegics.
References
Alcon Laboratories New Zealand Limited. Mydriacyl 0.5% and 1% Eye Drops data sheet 17 August 2020. Medsafe. http://www.medsafe.govt.nz/. Accessed 05/01/2021.

Anon. Tropicamide (EENT). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 05/01/2021.

Anon. Tropicamide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/01/2021.

Bausch & Lomb NZ Ltd. Minims Tropicamide Eye Drops Solution 0.5% and 1% data sheet 30 November 2018. Medsafe. http://www.medsafe.govt.nz/. Accessed 05/01/2021.

Buckingham R (ed). Tropicamide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/01/2021.

Minims Tropicamide 0.5% (Bausch & Lomb UK Limited). MHRA. https://products.mhra.gov.uk/. Accessed 05/01/2021.

Mydriacyl 0.5% Eye Drops Solution (Alcon Eye Care UK Limited). MHRA. https://products.mhra.gov.uk/. Accessed 05/01/2021.

Mydriacyl 1% Sterile Ophthalmic Solution (Alcon Laboratories [Malaysia] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my/. Accessed 19/01/2021.

Tropicamide Solution/Drops (Sandoz Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/01/2021.

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  • Mydriacyl
  • Mydriaticum
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