Trovafloxacin mesilate


Thông tin thuốc gốc
Chỉ định và Liều dùng
Intravenous
Complicated intra-abdominal infections, Gynaecological infections, Nosocomial pneumonia, Pelvic infections
Adult: 300 mg once daily as slow IV infusion over 60 min followed by 200 mg once daily by mouth. Treat for 10-14 days for nosocomial pneumonia and 7-14 days for gynaecological, pelvic and complicated intra-abdominal infections. Transfer to oral admin as soon as patient is able to tolerate.

Oral
Community-acquired pneumonia, Complicated skin and skin structure infections
Adult: 200 mg once daily. May also be given as slow IV infusion over 60 minutes followed by 200 mg once daily orally. Treat for 7-14 days for community acquired pneumonia and 10-14 days for complicated skin and skin structure infections, including diabetic foot infections.
Hepatic Impairment
Child-Pugh Class A and B: Use 200 mg IV instead if the normal dose used is 300mg IV. Use 100 mg IV or oral instead if the normal dose used is 200mg IV or oral. Child-Pugh Class C: avoid.
Cách dùng
May be taken with or without food.
Hướng dẫn pha thuốc
Dilute with a suitable volume of diluent (e.g. 5% Dextrose Inj, 0.45% Sodium Chloride Inj, 5% Dextrose and 0.45% Sodium Chloride Inj, 5% Dextrose and 0.2% Sodium Chloride Inj, Lactated Ringer's and 5% Dextrose Inj) to a concentration of 1-2 mg/ml and run as a infusion over 60 min.
Tương kỵ
Do not dilute with 0.9% Sodium Chloride Inj or Lactated Ringer's.
Chống chỉ định
Severe hepatic cirrhosis, hypersensitivity to quinolones. Adolescent<18 yr; lactation; pregnancy.
Thận trọng
Impaired hepatic function; G6PD deficiency; history of CNS disorders e.g. severe cerebral atherosclerosis, epilepsy. Avoid exposure to strong sunlight/sunlamp. Discontinue in case of pain, inflammation or rupture of tendon. Discontinue if phototoxicity or skin rash occurs. May impair ability to drive and operate machinery. Decrease incidence of drowsiness by taking at bedtime or with food. Perform liver function and pancreatic tests when symptoms develop. Increased risk of hepatotoxicity when used > 2 wk. Avoid rapid or bolus inj. Oral doses to be admin at least 2 hr before or 2 hr after magnesium or aluminum containing antacids, sucralfate, citric acid buffered with sodium citrate, metal cations (e.g. ferrous sulfate) and didanosine. IV morphine to be admin at least 2 hr after oral trovafloxacin in the fasted state and at least 4 hr after oral trovafloacin is taken with food.
Phản ứng phụ
Dizziness, convulsions, increased intracranial pressure, CNS stimulation (e.g. tremor, restlessness, hallucinations), pseudomembranous colitis, phototoxicity, pancreatitis.
Potentially Fatal: Hapatotoxicity, anaphylactic reactions, severe hypotension, Stevens-Johnson syndrome.
Quá liều
Symptoms: decreased activity and respiration, ataxia, ptosis, tremors and convulsions. Management: Empty stomach by inducing vomiting or by gastric lavage. Treatment is symptomatic and supportive with close monitoring. Maintain adequate hydration. Haemodialysis unlikely to be useful.
Tương tác
Decreased oral absorption with antacids containing aluminum and magnesium salts, citric acid/sodium citrate, strontium, sucralfate, vitamins or minerals containing iron or zinc and concomitant admin of IV morphine. Increased risk of convulsions with NSAIDs. Increased anticoagulant effect with acenocoumarol, warfarin.
Potentially Fatal: Increased risk of severe hypotension with general anaesthetic agents.
Tác dụng
Description: Trovafloxacin has actions and uses similar to those of ciprofloxacin, but is more active against pneumococci. It is available as trovafloxacin mesilate for oral admin and as alatrofloxacin mesilate inj (a prodrug of trovafloxacin) for IV admin. Due to reported incidences of hepatotoxicity, trovafloxacin should be used only in serious, life- or limb-threatening infections caused by susceptible strains.
Pharmacokinetics:
Absorption: Readily absorbed from GI tract. Peak plasma concentration: 1-2 hr. Oral bioavailability: 88%.
Distribution: Widely distributed and found in breast milk. Protein binding: 76%.
Metabolism: Metabolised by conjugation. Half-life: 9-12 hr. After IV inj, alatrofloxacin, the prodrug of trovofloxacin, is rapidly converted to trovafloxacin.
Excretion: Excreted in urine and faeces as metabolites and unchanged drug.
Bảo quản
Tab: Store at 15-30°C (59-86°F). Inj: Store at 15-30°C (59-86°F); protect from light; do not freeze.
Phân loại MIMS
Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Trovafloxacin mesilate từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2021 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
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