No data on concomitant administration of Twinrix with specific hepatitis A immunoglobulin or hepatitis B immunoglobulin have been generated. However, when the monovalent hepatitis A and hepatitis B vaccines were administered concomitantly with specific immunoglobulins, no influence on seroconversion was observed although it may result in lower antibody titres.
Clinical studies have demonstrated that Twinrix can be administered
concomitantly with diphtheria, tetanus, acellular pertussis, inactivated
poliomyelitis, Haemophilus influenzae
type b (DTPa-IPV/Hib) or Measles-Mumps-Rubella vaccines in the second year of life.
In these trials, the injectable vaccines were given at different injection
Although the concomitant administration of Twinrix and other vaccines has not
specifically been studied, it is anticipated that, if different syringes and
other injection sites are used, no interaction will be observed.
It may be expected that in patients receiving
immunosuppressive treatment or patients with immunodeficiency, an adequate
response may not be achieved.