Vaccine, meningococcal


Thông tin thuốc gốc
Chỉ định và Liều dùng
Intramuscular
Meningococcal disease, prophylaxis
Adult: As N. meningitidis serogroup B vaccine (recombinant, adsorbed): Bexsero 2 doses of 0.5 mL given at least 1 mth apart. Trumenba 2 doses of 0.5 mL given at 6 mth interval; or 3 doses of 0.5 mL w/ the 1st 2 doses at least 1 mth apart followed by a 3rd dose at least 4 mth after the 2nd dose. As N. meningitidis serogroup C or ACWY conjugate vaccine (conjugated to diphtheria CRM197 or tetanus toxoid carrier protein): Single dose of 0.5 mL.
Child: As N. meningitidis serogroup B vaccine (recombinant, adsorbed): Bexsero 2-5 mth 3 doses of 0.5 mL at least 1 mth apart. Booster dose of 0.5 mL is given between 12-15 mth or not later than 24 mth of age; 6-11 mth (unvaccinated) 2 doses of 0.5 mL given at least 2 mth apart. Booster dose of 0.5 mL is given at 2 yr of age, w/ at least 2 mth interval from the primary series; 12-23 mth (unvaccinated) 2 doses of 0.5 mL given at least 2 mth apart. Booster dose of 0.5 mL is given 12-23 mth apart from the primary series; 2-10 yr 2 doses of 0.5 mL given at least 2 mth apart; ≥11 yr Same as adult dose. Trumenba ≥10 yr Same as adult dose. As N. meningitidis serogroup C vaccine (conjugated to diphtheria CRM197 protein): 2-12 mth 2 doses of 0.5 mL given at least 2 mth apart. Booster dose may be given based on national recommendations; >12 mth Same as adult dose. As N. meningitidis serogroup C vaccine (conjugated to tetanus toxoid carrier protein): 2-4 mth 2 doses of 0.5 mL given at least 2 mth apart. Booster dose of 0.5 mL is given at 12-13 mth of age w/ an interval of 6 mth after the last vaccination; >4 mth Same as adult dose. As N. meningitidis serogroup ACWY vaccine (conjugated to diphtheria CRM197 protein): ≥2 yr Same as adult dose. Booster dose of 0.5 mL may be given based on national recommendations. As N. meningitidis serogroup ACWY vaccine (conjugated to tetanus toxoid carrier protein): 6 wk to 12 mth 2 doses of 0.5 mL given at least 2 mth apart. Booster dose of 0.5 mL is given at 12 mth of age; >12 mth Same as adult dose. Booster dose of 0.5 mL may be given based on national recommendations.

Subcutaneous
Meningococcal disease, prophylaxis
Adult: As unconjugated N. meningitidis serogroup ACWY vaccine: Single dose of 0.5 mL.
Child: As unconjugated N. meningitidis serogroup ACWY vaccine: ≥2 yr Same as adult dose.
Chống chỉ định
Hypersensitivity. Acute severe febrile illness.
Thận trọng
Patient w/ asplenia, acute malaria, thrombocytopenia, coagulation disorder, history of resp immaturity. Immunocompromised patients. Minor febrile and mild upper resp infection is not a reason to postpone immunisation. Childn. Pregnancy and lactation.
Phản ứng phụ
Significant: Anxiety-related reactions, hyperventilation or stress-related reactions, vasovagal reactions (e.g. syncope), post-vaccination febrile reactions, apnoea (premature infants), haematoma. Rarely, symptoms of meningism (e.g. neck pain/stiffness, photophobia).
Nervous: Drowsiness, impaired sleeping, unusual crying, headache, dizziness, seizures (including febrile seizures), irritability, malaise, fatigue, transient neurological reactions.
GI: Eating disorder (e.g. anorexia), diarrhoea, nausea, vomiting.
Resp: Wheezing.
Musculoskeletal: Arthralgia, myalgia.
Dermatologic: Pallor, rash, eczema, severe local reactions.
Immunologic: Angioedema.
Others: Fever, inj site reactions (e.g. swelling, erythema, tenderness/pain).
Potentially Fatal: Hypersensitivity reactions (e.g. anaphylaxis).
Thông tin tư vấn bệnh nhân
This drug may cause dizziness, if affected, do not drive or operate machinery.
MonitoringParameters
Resp monitoring for 48-72 hr in premature infants and patient w/ history of resp immaturity.
Tương tác
Immunosuppressive drugs may reduce the immune response to meningococcal vaccine.
Tác dụng
Description: Meningococcal vaccine contains purified polysaccharide antigens from Neisseria meningitidis (N. meningitidis). It is available either as monovalent which contains one serotype antigen or polyvalent, containing 2 or more serotypes antigen. It can also be conjugated to a carrier protein (e.g. diphtheria CRM197, tetanus toxoid) to increase immunogenicity. It stimulates the production of bactericidal antibodies against N. meningitidis serogroups A, C, W-135, Y (ACWY), and B. It is usually given via IM route w/ SC route reserved for patients w/ bleeding disorder.
Bảo quản
Store between 2-8°C. Do not freeze. Protect from light.
Phân loại ATC
J07AH - Meningococcal vaccines ; Used for active immunizations.
References
Anon. Meningococcal Group B Vaccine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/08/2017.

Anon. Meningococcal Groups A, C, Y, and W-135 Vaccine. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 04/08/2017.

Anon. Meningococcal Polysaccharide Vaccine (Groups A/C/Y and W-135). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/08/2017.

Buckingham R (ed). Meningococcal Vaccines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/08/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Meningococcal Group B Vaccine. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 04/08/2017.

Sanofi-Aventis New Zealand Limited. Menomune ACYW-135 Vaccine data sheet 7 June 2013. Medsafe. http://www.medsafe.govt.nz/. Accessed 08/08/2017.

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  • Polysaccharide Meningococcal A+C
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