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  • Lidocaine - MIMS.com
Lidocaine

Tác Động
Description: Lidocaine is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.
Onset: 45-90 sec (IV); approx 4 hr (transdermal); 20 sec to 5 min (ophth). .
Duration: 10-20 min (IV); 5-30 min (ophth).
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract, mucous membranes, damaged skin, inj sites, including muscle; poor absorption through intact skin.
Distribution: Crosses the placenta, blood-brain barrier and enters breast milk. Protein-binding: 66% (α1-acid glycoprotein).
Metabolism: Undergoes rapid metabolism and approx 90% is dealkylated to monoethylglycinexylidide and glycinexylidide. First-pass metabolism is extensive.
Excretion: Via urine (<10% unchanged). Elimination half-life: biphasic; initial: 7-30 min; terminal: 1.5-2 hr.


Phân loại MIMS
Thuốc gây mê-gây tê Anaesthetics - Local & General  /  Thuốc tim Cardiac Drugs



Sản phẩm đang lưu hành
Axcel Lignocaine 2% Sterile Gel [ Kotra Pharma ] Lidocain 10% Egis [ Egis ]
Lidocain 2% Egis [ Egis ] Lignopad [ Mundipharma ]

Sản phẩm khác
Lidocain Bidiphar [ Bidiphar ] Lidocain Pymepharco 1%/2% [ Pymepharco ]
Lidocain Thephaco [ Thephaco ] Lidocain Uphace [ Uphace (CTCPDP TW.25) ]
Rotexmedica Lignocaine [ Rotexmedica ] Xylocaine Inj [ AstraZeneca ]
Xylocaine jelly [ AstraZeneca ] Xylocaine Naphtazoline [ AstraZeneca ]
Xylocard [ AstraZeneca ]

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