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Omeprazole

Tác Động
Description: Omeprazole is a substituted benzimidazole gastric antisecretory agent and is also known as proton pump inhibitor (PPI). It blocks the final step in gastric acid secretion by specific inhibition of adenosine triphosphatase (ATPase) enzyme system present on the secretory surface of the gastric parietal cell. Both basal and stimulated acid are inhibited.
Onset: Antisecretory: Approx 1 hour.
Duration: Up to 72 hours.
Pharmacokinetics:
Absorption: Rapid but variably absorbed from the gastrointestinal tract. Bioavailability: Approx 30-40%. Time to peak plasma concentration: 0.5-3.5 hours.
Distribution: Enters breast milk. Plasma protein binding: Approx 95%.
Metabolism: Metabolised in the liver primarily by CYP2C19 isoenzyme to hydroxyl-omeprazole; and lesser extent by CYP3A4 to omeprazole sulfone.
Excretion: Mainly via urine (approx 77% as metabolites, small amount as unchanged drug); faeces (small amount). Elimination half-life: 0.5-3 hour.


Phân loại MIMS
Thuốc kháng acid, chống trào ngược & chống loét Antacids, Antireflux Agents & Antiulcerants

Phân loại ATC
A02BC01 -  omeprazole;  Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).; 


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