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Radiofrequency vs pulsed field ablation: Which approach results in fewer stroke/TIA events?
A single-centre study has found a significantly higher incidence of stroke and transient ischaemic attacks (TIA) within 30 days among patients who underwent pulsed field ablation (PFA) relative to those who received radiofrequency ablation (RFA).
Radiofrequency vs pulsed field ablation: Which approach results in fewer stroke/TIA events?
25 Apr 2026
Lowering BP threshold to 130/80 mm Hg enhances hypertension diagnosis
A significant number of masked, sustained, and nighttime hypertension may not be detected when using the conventional home blood pressure (BP) threshold of 135/85 mm Hg, suggests a study.
Lowering BP threshold to 130/80 mm Hg enhances hypertension diagnosis
24 Apr 2026
Statin-ezetimibe holds slight advantage over PCSK9is in ACS
In a systematic review and network meta-analysis (NMA), a statin-ezetimibe combination yields a more favourable LDL-C reduction and a positive trend in atherosclerotic plaque regression compared with PCSK9 inhibitors (PCSK9is) alone in individuals with acute coronary syndrome (ACS).
Statin-ezetimibe holds slight advantage over PCSK9is in ACS
24 Apr 2026
SONIA: Does 1L vs 2L use of CDK4/6 inhibitors improve OS in HR+, ERBB2- ABC?
A phase III randomized clinical trial (RCT) of 1,050 patients with hormone receptor–positive (HR-positive), ERBB2-negative advanced breast cancer (ABC) showed that first-line (1L) use of cyclin-dependent kinase (CDK) 4 and 6 inhibitors did not improve overall survival (OS) compared with second-line (2L) use. At the same time, a post hoc subgroup analysis suggested an OS benefit with 1L use of CDK4/6 inhibitors in premenopausal patients.
