Urinary Tract Infection - Uncomplicated Disease Summary

Last updated: 27 April 2026

Overview

Acute uncomplicated urinary tract infection (UTI) is one of the most common bacterial infections in adults that may involve the lower and/or upper urinary tract, as stated in the Introduction section.

Urinary tract infection is among the most common bacterial infections, especially in women. A detailed discussion about the prevalence of urinary tract infection is in the Epidemiology section.

Bacteria is the most common cause of urinary tract infection, with Escherichia coli constituting approximately 70–95% of cases. Discussion on these pathogens is in the Etiology section.

The Pathophysiology section states that the most common route of urinary tract infection is the ascending spread of bacteria from the urethra to the bladder. The developmental process of urinary tract infection in infected patients is in this section.

Conditions associated with the development of urinary tract infection are in the Risk Factors section.

The Classification section enumerates the urinary tract infection categories based on the 2025 European Association of Urology (EAU) guidelines.



Urinary Tract Infection - Uncomplicated_Disease SummaryUrinary Tract Infection - Uncomplicated_Disease Summary

History and Physical Examination

The Clinical Presentation section describes the clinical features suggestive of acute uncomplicated cystitis and acute uncomplicated pyelonephritis.

The History section and the Physical Examination section enumerate important symptoms and examination findings to note in the evaluation of patients suspected of urinary tract infection.

Diagnosis

Discussions on the different diagnostic studies such as urinalysis, urine dipstick, and culture are in the Laboratory Tests and Ancillaries section. 

The Imaging section discusses the diagnostic tests and indications for imaging in patients with suspected urinary tract infections.

Other conditions that should be ruled out in the diagnosis of acute uncomplicated urinary tract infection are listed in the Differential Diagnosis section.

Management

Indications for hospital admission in acute uncomplicated urinary tract infections are enumerated in the Evaluation section.

General therapy principles in the management of uncomplicated urinary tract infection are in the Principles of Therapy section.

The Pharmacological Therapy section discusses the therapeutic options in patients diagnosed with acute uncomplicated cystitis, acute uncomplicated pyelonephritis, and recurrent urinary tract infection.

The Nonpharmacological section includes antibiotic-sparing treatment and prevention options in acute uncomplicated cystitis and behavioral modification in recurrent urinary tract infection.

The Monitoring section identifies indications for follow-up in acute uncomplicated cystitis and acute uncomplicated pyelonephritis.

Discussion about complicated urinary tract infection is in the Complications section.