Pancreatitis - Acute Disease Summary

Last updated: 25 June 2025

Overview

Acute pancreatitis is an inflammatory condition of the pancreas characterized histologically by destruction of the acinar cells which is most commonly caused by excessive alcohol use or by gallstones.
Abdominal pain is the most prominent symptom of acute pancreatitis.
It is diagnosed by at least two of the following: Characteristic abdominal pain, serum lipase and/or amylase levels ≥3 times the upper limit of normal and characteristic abdominal imaging findings.
Consider performing interventions (eg percutaneous or endoscopic drainage) for pancreatic necrosis if 4 weeks after disease onset patient has ongoing organ failure with no sign of infected necrosis, ongoing gastric outlet, biliary or intestinal obstruction from a walled-off necrotic collection, disconnected duct syndrome, or growing or symptomatic pseudocyst; or ongoing discomfort and/or pain 8 weeks after disease onset.

For further information regarding the management of Pancreatitis - Acute, please refer to Disease Algorithm for the Treatment Guideline.