Multidisciplinary

Top Medical News
Safety and efficacy of vitamin B in cancer treatments: A systematic review
19 minutes ago
Supplementation with vitamin B may or may not reduce the risk of certain cancers, with varying effects depending on the type of cancer and vitamin B compounds, according to a study.
Cognitive impairment may augment healthcare burden in SG
Stephen Padilla, an hour ago
An ageing population and a greater incidence of cognitive impairment (CI) are expected to put a strain on healthcare resources through the increased use of emergency department (ED) visits and unplanned admissions, suggests a Singapore study.
Newborns with congenital disease prone to severe RSV infection
2 hours ago
Infants aged <1.5 months with cardiovascular or congenital/genetic diseases are at higher risk of severe respiratory syncytial virus (RSV) infection, according to a Taiwan study. Use of RSV monoclonal antibody (mAb) prophylaxis appears beneficial in these children.
48-week data ASSERT odevixibat’s role in ALGS
Audrey Abella, 3 hours ago
Pooled analysis of the ASSERT and ASSERT-EXT studies show sustained improvements in multiple parameters with odevixibat in individuals with Alagille syndrome (ALGS), thus reinforcing its role in the treatment of this multisystem genetic disorder.
SABR hits efficacy, safety targets for NSCLC with interstitial lung disease
7 hours ago
In the treatment of patients with interstitial lung disease (ILD) and early-stage non–small cell lung cancer (NSCLC), stereotactic ablative radiotherapy (SABR) has met the prespecified acceptability thresholds for both toxicity and efficacy, according to the single-arm, phase II ASPIRE-ILD study.
Dupilumab sustains histological remission in children with EoE
Elaine Soliven, 13 hours ago

Treatment with higher-dose dupilumab results in sustained improvements in histologic and endoscopic measures of eosinophilic esophagitis (EoE) in children, regardless of prior use of swallowed topical corticosteroids (STCs), according to a subanalysis presented at ESPGHAN 2024.

Can mental disorders spread among teens within peer groups?
Jairia Dela Cruz, 23 hours ago
A Finnish teen study suggests that mental disorders may be transmitted socially via peer networks, such that having friends who have a diagnosis of mental disorders may put adolescents at risk of receiving one themselves.
Special Reports
New study findings show significant
rise in Hb levels in 14 days, symptom relief
in 30 days & improved quality of life in w
01 May 2024
A recent study carried out in the Philippines has revealed that a readily available supplement consisting of ferrous gluconate, multivitamin and minerals, is able to combat iron deficiency anaemia (IDA) in women. Also known as the SANOIN study , the clinical trial was an open-label, phase IV, single arm observational study conducted at six sites in the Philippines.
Debunking the myths about DPP-4 inhibitors
01 May 2024
Navigating the evolving landscape of diabetes management requires precise knowledge. In this exploration into the world of DPP-4 inhibitors (DPP4is), we aim to debunk prevalent myths and provide nuanced insights.
Optimising Treatment in Myelofibrosis, Considerations for Ruxolitinib Resistance
01 Apr 2024
At the recent MPN Expert Forum virtual symposium, Professor Claire Harrison shared her experience in managing real-world myelofibrosis and further discussed treatment options in the event of ruxolitinib failure.
SGLT-2i – The standard of care,
first-line treatment for patients
with T2DM and CKD
29 Mar 2024
The role of a sodium/glucose cotransporter-2 inhibitor in managing patients with type 2 diabetes mellitus and chronic kidney disease were discussed by experts during the EMPIRE Summit 2023.
The role of oral anticoagulant
with direct thrombin
inhibition in atrial fibrillation
28 Mar 2024
Atrial fibrillation was the focus of discussion during a Boehringer Ingelheim-sponsored symposium in conjunction with the Malaysian Heart Rhythm Society Summit 2023. A panel of experts consisting of two Consultant Cardiologists and a Consultant Neurologist had a lively conversation on evidence-based practices in the management of atrial fibrillation. Some of the key points are presented here.
Nirmatrelvir reduces the risk of long COVID
05 Mar 2024

Post-COVID condition, also known as long COVID, is a serious public health problem affecting millions of people around the world.1

SGLT-2i/GLP-1 RA/DPP-4i combination
treatment for cardio-renal-metabolic
protection in T2DM patients
01 Mar 2024
The role of combining a sodium glucose cotransporter-2 inhibitor and either a glucagon-like peptide-1receptor agonist or dipeptidyl peptidase-4 enzyme inhibitor in managing patients with type 2 diabetes mellitus, cardiovascular disease and chronic kidney disease were discussed by experts during the EMPIRE Summit 2023.
Conference Reports
Dupilumab sustains histological remission in children with EoE
Elaine Soliven, 29 May 2024

Treatment with higher-dose dupilumab results in sustained improvements in histologic and endoscopic measures of eosinophilic esophagitis (EoE) in children, regardless of prior use of swallowed topical corticosteroids (STCs), according to a subanalysis presented at ESPGHAN 2024.

Diversity of children included in clinical trials
Mike Ng, 28 May 2024
Maralixibat may have a role in treating a broader profile of children with PFIC, including those who have had biliary diversion surgery and those with MDR3 deficiency, suggest subgroup analyses from the phase III MARCH/MARCH-ON trials
High-resolution anorectal manometry detects HD in children ≤2 years old
Elvira Manzano, 28 May 2024
High-resolution anorectal manometry (HRARM) can be a noninvasive primary screening tool for Hirschsprung’s disease (HD), particularly in children ≤2 years old, as shown in a comprehensive retrospective analysis.
Shorter antibiotic duration tied to higher mortality in infants with E. coli bacteremia
Elaine Soliven, 25 May 2024

Shorter course of antibiotics was associated with higher mortality rates in infants with Escherichia coli (E. coli) bacteremia who did not undergo a cerebrospinal fluid (CSF) evaluation compared with longer antibiotic courses, according to a recent study presented at PAS 2024.

Gepotidacin as good as current standard treatment for urogenital gonorrhoea
Elvira Manzano, 24 May 2024
The oral investigational antibiotic gepotidacin is noninferior to the current standard treatment for uncomplicated urogenital gonorrhoea in the randomized, multicentre, phase III EAGLE-1 trial.
Mum’s infection during pregnancy may raise newborn’s risk of IBD
Jairia Dela Cruz, 23 May 2024
Exposure to any infection during early pregnancy or to a gastrointestinal infection during late pregnancy contributes to the increased likelihood of inflammatory bowel disease (IBD) development, especially Crohn’s disease, in the offspring, according to a study.
Children, teens with EoE respond to budesonide oral suspension
Jairia Dela Cruz, 22 May 2024
Budesonide oral suspension is well tolerated and superior to placebo at inducing remission in paediatric patients with eosinophilic esophagitis (EoE), with the high-dose formulation offering the best results, according to the results of the phase II/III PEDEOS-1 trial.