Top Medical News
Veterans with higher traumatic brain injury predisposed to subsequent brain cancer
7 hours ago
Veterans of Iraq and Afghanistan who sustained moderate/severe and penetrating traumatic brain injury (TBI) are at increased risk of developing brain cancer, as shown in a study.
Well-managed blood sugar through multidisciplinary care can stave off dementia in T2D patients
Jairia Dela Cruz, 11 hours ago
A multidisciplinary intervention program for type 2 diabetes (T2D) in the primary care setting subsequently reduces the incidence of dementia, as reported in a study.
5-year survival more likely in mBCC patients with nodal vs distant metastasis
12 hours ago
Among patients with metastatic basal cell carcinoma (mBCC), those with nodal disease appear to have a higher chance of remission, while individuals with distant metastasis tend to have persistent disease and subsequently die from it, a recent study reveals. However, the survival rates at 5 years surpass 50 percent even for those with stage IV disease.
SG Framingham Risk Score needs recalibration to improve prediction accuracy
Stephen Padilla, 13 hours ago
Current guidelines that are being used in Singapore (SG) for predicting cardiovascular disease (CVD) must be updated to improve risk prediction accuracy. This can be done by recalibrating risk functions and employing wearable metrics that provide a huge amount of objective health data, suggests a study.
Patch test a boon to dupilumab-treated patients
14 hours ago
A prospective, multicentre study has demonstrated the efficacy of patch tests (PTs) for patients who are being treated with dupilumab.
COVID-19 shots offer durable protection in IBD population
19 hours ago
Adults with inflammatory bowel disease (IBD) benefit from COVID-19 vaccination, with its protective effect lasting up to 52 weeks postvaccination even among vulnerable populations such as corticosteroid users and older individuals, according to a study.
Dexmedetomidine use raises body temp in ICU patients with obesity
Critically ill patients with obesity see a significant rise in their body temperature following the use of dexmedetomidine (DEX) for ongoing sedation, as shown in a recent study. Furthermore, DEX duration and baseline temperature are significantly associated with fever development in these individuals.
Special Reports
COVID-19, influenza, death, hospital admission, adverse outcome
07 Feb 2024
A comparative analysis has shown that COVID-19 is distinctly more severe than seasonal influenza, with significantly increased long-term risks of adverse health outcomes and burdens.1
fenofibrate, metabolic syndrome, statins, omega-3 fatty acids, MACE
05 Feb 2024
A nationwide population-based cohort study in South Korea compared the effectiveness of omega-3 fatty acids and fenofibrate for reducing major adverse cardiovascular events (MACE) in individuals with metabolic syndrome (≥30 years) on statin therapy.1
Treating type 2 diabetes mellitus with G.R.A.C.E.
22 Jan 2024
A challenging aspect of glycaemic control presents in patients diagnosed with early-onset type 2 diabetes mellitus (T2DM). Considering this challenge, how can effective management of glycaemic control be achieved in patients with uncontrolled T2DM who are hesitant to incorporate multiple oral antidiabetic drugs into their current regimen? In this case study, Dr Matthew Tan shared his clinical experience in managing a young adult patient with T2DM using GLYXAMBI®, a fixed-dose combination of empagliflozin and linagliptin taken once daily. He demonstrated how applying the G.R.A.C.E. concept to the treatment improved the patient’s clinical outcome.

This advertorial is sponsored as an educational programme by Boehringer Ingelheim Singapore Pte. Ltd.
Effectiveness of mRNA Vaccines Against Omicron XBB Infection in Singaporean Children Under 5: A Population-Based Cohort Study
22 Jan 2024
Limited data exists on COVID-19 mRNA vaccine effectiveness in children aged 1–4 years, particularly against Omicron subvariants. In a cohort study conducted during Omicron XBB subvariant predominant period in Singapore, completing the primary COVID-19 mRNA vaccine series significantly protected against COVID-19 infection in this age group, with 45.2% and 63.3% vaccine effectiveness in partially and fully vaccinated children, respectively. Vaccine effectiveness was also robust at 74.6% in children with prior COVID-19 infection who received at least one vaccine dose.
Nicorette® QuickMist Launch Symposium
19 Jan 2024
During the launch of Nicorette® QuickMist at the Kuala Lumpur Nicotine Addiction International Conference (KLNAC) 2023, a panel of distinguished experts led the discussion on the role of Nicotine Replacement Therapy (NRT) on smoking cessation management. The panel comprised of notable experts, including Professor Chris Bullen (New Zealand), Associate Professor Dr Amer Siddiq bin Amer Nordin (Malaysia), Dr Philip Tønnesen (Denmark) and Professor Philip Eng (Singapore).
COVID-19, nirmatrelvir, ritonavir, mRNA vaccine, Omicron, COPD, CDC, WHO
Dr. Chan Kwok Wai Adrian, Prof. Yang Kuang-Yao, 10 Jan 2024
At the 27th Congress of the Asian Pacific Society of Respirology (APSR) 2023, a Pfizer-sponsored symposium addressed the evolving challenges of COVID-19, particularly for patients with pre-existing respiratory conditions. Chaired by Dr Chan Kwok Wai Adrian, a renowned respiratory physician and intensivist from Mount Elizabeth Novena Hospital, Singapore, and featuring insights from Professor Yang Kuang-Yao of National Yang Ming Chiao Tung University, Taipei, Taiwan, the symposium focused on the disease’s impact, treatment guidelines, regional management strategies, and the role of nirmatrelvir/ritonavir, a new oral combination pill, in the treatment of COVID-19.
Navigating invasive fungal infections in unconventional hosts — insights and strategies
Assoc Prof. Carolina García-Vidal, Dr. Jasmine Chung, 06 Jan 2024

At a recent symposium organized by Pfizer, in collaboration with the Society of Infectious Disease Singapore, A/Prof Carolina García-Vidal, Senior Specialist, Infectious Diseases Department at Hospital Clínic de Barcelona, Spain, shared valuable insights on managing invasive fungal infections (IFIs) in nontraditional hosts. The session was chaired by Dr Jasmine Chung, Senior Consultant and Director of the Antimicrobial Stewardship Unit, Singapore General Hospital.

Conference Reports
Reteplase a good alternative to alteplase in acute ischaemic stroke
Stephen Padilla, 20 Feb 2024
Treatment with reteplase appears more effective than alteplase in patients with acute ischaemic stroke (AIS) who have been treated within 4.5 hours of symptom onset, according to the results of RAISE, a phase III multicentre, open-label, randomized controlled, noninferiority trial.
Metformin offers no benefit for pre-eclampsia in pregnant women with diabetes
Jairia Dela Cruz, 19 Feb 2024
Adding metformin to insulin neither lowers the risk of developing preterm pre-eclampsia nor improves the risk markers of cardiovascular disease in pregnant women who have received a diagnosis of diabetes early in pregnancy or have existing type 2 diabetes mellitus, according to a study.
AI helps improve care quality in stroke patients
Stephen Padilla, 19 Feb 2024
Use of artificial intelligence (AI) as part of the support system can greatly improve the quality of care in patients who just had a stroke and may even prevent the occurrence of various vascular events in the future, according to a study presented at ISC 2024.
HK data validate cerebrovascular safety of BNT162b2, CoronaVac vaccines
Audrey Abella, 19 Feb 2024
A Hong Kong study finds no association between the BNT162b2 and CoronaVac vaccines and subclinical progression of MRI cerebrovascular disease biomarkers in community-dwelling adults.
ART linked to higher stroke risk during delivery
Elaine Soliven, 19 Feb 2024

Women who underwent assisted reproductive technology (ART) were significantly more likely to experience strokes during delivery hospitalization than those who did not use ART, according to a study presented at ISC 2024.

AI as accurate as neurologists in detecting acute stroke, Bell’s palsy
Jairia Dela Cruz, 18 Feb 2024
A novel smartphone app that uses machine learning algorithms to analyse facial expressions, speech patterns, and arm movements can detect acute stroke and Bell’s palsy with an accuracy matching that of neurologists, as shown in a study.
Adalimumab response prevents serious infections in CD
Stephen Padilla, 18 Feb 2024
The risk of developing serious infections is much lower among patients with Crohn’s disease (CD) who showed response to adalimumab therapy than nonresponders, after accounting for disease severity, according to the results of a study presented at CCC 2024.