Safe genome-edited, immune-evasive human stem cells promising for therapeutic use
Researchers from the University of Hong Kong (HKU), in collaboration with the Lunenfeld-Tanenbaum Research Institute at Sinai Health in Toronto, Canada, have genetically engineered human stem cells that can ‘cloak’ themselves to evade immune rejection while carrying a built-in kill-switch to prevent tumour formation, supporting potential application of safe, off-the-shelf therapeutic cells generated in vitro for transplantation in stem cell–based regenerative therapies.
