Obesity Disease Summary

Last updated: 25 May 2026

Overview

Obesity is a common chronic condition that impairs one's health and is defined in the Introduction section. Other terms relating to obesity are also defined in this section.

The prevalence of obesity regionally is high as reported by The Global Nutrition Report (GNR) and World Obesity Federation (WOF). A detailed discussion about this data is featured in the Epidemiology section.  

The Pathophysiology and Etiology sections provide an explanation on the causes of the development of obesity.

Absolute risk status can be identified based on the presence of certain disease conditions, obesity-associated diseases, cardiovascular diseases and other factors and these are enumerated in the Risk Factors section. 



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History and Physical Examination

Information that is necessary in diagnosing obesity should be elicited and this is listed in the History section.

In the Physical Examination section, aside from taking the patient’s blood pressure and assessing the mental status, anthropometric measures to be taken to classify the severity of the patient’s obesity are discussed. 

Diagnosis

Several laboratory tests and imaging modalities to be done to assess the comorbidities associated with obesity are included in the Laboratory Tests and Ancillaries and Imaging sections.

Alternative diagnoses for obesity are in the Differential Diagnosis section.

Management

The goals of treatment, management strategies and advantages of weight loss in obese patients are discussed in the Principles of Therapy section.

Factors to consider in choosing a therapeutic agent for obese patients and drug options that may aid in the management of obesity such as glucagon-like peptide-1 (GLP-1) receptor agonists, norepinephrine agents and Orlistat are analyzed in the Pharmacological Therapy section.

Several non-drug options to consider that may aid in the management of obesity, which include diet restriction or modification, are featured in the Nonpharmacological section. Surgery (eg bariatric surgery, metabolic surgery) is also a treatment option in severely obese patients, and this is further elaborated in the Surgery section.

Frequently Asked Questions

How is obesity classified in Asian adults?
Obesity assessment includes body mass index, waist circumference, and waist-to-hip ratio. Asian populations use lower BMI cut-off points than WHO values. Central obesity is classified using waist circumference thresholds of ≥90 cm in Asian men and ≥80 cm in Asian women, with repeat measurement useful for screening and treatment monitoring. Read more 
What laboratory tests assess obesity complications?
Laboratory testing helps detect, assess, and monitor obesity-related comorbidities. Tests may include lipid profile, fasting glucose, HbA1c, thyroid function tests, uric acid, liver function tests, renal function tests, and urine free cortisol when Cushing’s syndrome is suspected. Additional tests may be selected according to clinical risk. Read more  
What are the treatment goals in obesity?
Obesity treatment aims to reduce weight, prevent further weight gain, maintain weight loss, and lower obesity-related health risks. Management should also improve comorbidities, functional status, and quality of life. Goals should be individualized, realistic, and supported by long-term follow-up. Read more
What lifestyle measures support obesity management?
Lifestyle intervention is the foundation of obesity management. It includes dietary modification, increased physical activity, behavioral strategies, and sustained patient education. Clinicians should address barriers to adherence and provide structured follow-up because long-term weight control requires continuous lifestyle support. Read more
When is bariatric surgery considered for obesity?
Bariatric surgery may be considered for selected patients with severe obesity, particularly when obesity-related comorbidities are present and non-surgical treatment has not achieved adequate results. Suitability requires multidisciplinary assessment, perioperative risk evaluation, nutritional counselling, and commitment to long-term monitoring after surgery. Read more