Medication nonadherence more common in young vs older adults with SLE
3 giờ trước
Self-reported medication nonadherence is greater among younger vs older adults with systemic lupus erythematosus (SLE), driven primarily by logistical barriers, reports a study.
A significant difference was observed in medication nonadherence across age groups 18‒29, 30‒39, 40‒49, and 50+ years (p<0.001). Self-reported nonadherence dropped by 2 percent for every increase in year of age (p<0.05).
Individuals in the <30-year age group had a higher likelihood of reporting nonadherence due to inability to fill medications on time (odds ratio [OR], 3.72, 95 percent confidence interval [CI], 1.53‒9.02) and needing time to take medicines with food (OR, 2.55, 95 percent CI, 1.06‒6.13).
Furthermore, Black race and Hispanic ethnicity correlated with nonadherence across age groups.
“In addition to counselling young adults with SLE on the importance of medications, rheumatologists should, when possible, offer support to help them overcome challenges in obtaining and taking medicines,” the researchers said.
“Approaches to understanding and intervening on medication nonadherence in SLE may need to be tailored by age,” they added.
In this study, the researchers collected responses to the Domains of Subjective Extent of Nonadherence-SLE questionnaire, a clinical tool validated to measure the extent of and reasons for medication nonadherence in SLE.
A total of 336 surveys completed between February 2020 and June 2024 were included in the analysis. The researchers then evaluated the proportions and ORs for the extent of and reasons for nonadherence across age groups. They also assessed the associations of nonadherence with age and other covariates using logistic regression.