Unresolved dyshaematopoiesis & hypersensitivity to acemetacin or indomethacin, NSAIDs/analgesics. Patients who suffer from asthma, hay fever, swollen nasal mucosa or chronic respiratory disease. Patients w/ gastric & duodenal ulcers. Severe heart failure. Treatment of peri-op pain in the setting of CABG surgery. History of GI bleeding or perforation, related to previous NSAIDs therapy; active or history of recurrent peptic ulcer/haemorrhage. Pregnancy & lactation.