View Azarga overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to brinzolamide & timolol, other β-blockers, or to sulphonamides. Bronchial asthma, severe COPD. Sinus bradycardia, sick sinus syndrome, SA block, 2nd or 3rd degree AV block not controlled w/ pace-maker, overt cardiac failure, cardiogenic shock. Severe allergic rhinitis. Hyperchloraemic acidosis. Severe renal impairment.
Patients w/ severe peripheral circulatory disturbance/disorders; pseudoexfoliative glaucoma or pigmentary glaucoma. Choroidal detachment. Not recommended in patients w/ narrow-angle glaucoma. Concomitant use w/ other systemic β-blockers or carbonic anhydrase inhibitors. Contains benzalkonium Cl. Severe hepatic impairment. Temporary blurred vision or other visual disturbances may affect ability to drive or use machines. Pregnancy & lactation. Childn ≤18 yr. Timolol: Patients w/ CV diseases & hypotension; 1st degree heart block; mild/moderate COPD; history of atopy or a history of severe anaphylactic reaction to a variety of allergens. May mask signs of hyperthyroidism & signs & symptoms of acute hypoglycaemia. Muscle weakness. May block systemic β-agonist effects of adrenaline. May induce dryness of eyes. Brinzolamide: Acid/base disturbances. Patients w/ risk of renal impairment. May impair mental alertness. May affect corneal hydration.
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