Angioedema & anaphylaxis. Observe for signs of superinfection. Caution in patients w/ neurological & psychiatric disorders; diabetic patients. Drugs known to prolong QT interval. Clostridium difficile
-associated diarrhea (CDAD); QT prolongation; myasthenia gravis; dermatologic reactions eg, Drug Reaction w/ Eosinophilia & Systemic symptoms (DRESS). Exclude concomitant infection by T. palladium
. Not the 1st choice for treatment of pharyngitis & tonsilitis caused by Streptococcus pyogenes
; sinusitis; acute otitis media. Not indicated for infected burn wounds. Rare hereditary galactose intolerance, lactose deficiency or glucose-galactose malabsorption. Use for Mycobacterium Avium
Complex in childn has not been established. Co-administration of ergot derivatives. Significant hepatic disease. Stop if liver dysfunction has emerged. Severe renal impairment (GFR <10 mL/min). Pregnancy & lactation.