1,600 mg daily as a single dose. Dose exceeding 1,600 mg must be taken separately (as a 2nd dose).
Hypercalcemia 2,400-3,200 mg daily, may be reduced to 1,600 mg daily if applicable.
Osteolysis Initially 1,600 mg daily, may be increased to a max of 3,200 mg daily if necessary.
Renal insufficiency CrCl 50-80 mL/min 1,600 mg daily,
30-50 mL/min 1,200 mg daily,
<30 mL/min 800 mg daily.