Search

Desferal

Desferal

deferoxamine

Manufacturer:

Novartis

Distributor:

Zuellig
Concise Prescribing Info
Contents
Desferrioxamine methane sulfonate
Indications/Uses
Monotherapy Fe chelation treatment for chronic Fe overload eg, transfusional hemosiderosis, as seen in thalassemia major, sideroblastic anemia, auto-immune hemolytic anemia & other chronic anemias. Idiopathic (primary) hemochromatosis in patients in whom concomitant disorders (eg, severe anemia, cardiac disease, hypoproteinemia) preclude phlebotomy. Fe overload associated w/ porphyria cutanea tarda in patients unable to tolerate phlebotomy. Treatment for acute Fe poisoning. Treatment for chronic Al overload in patients w/ end-stage renal failure (under maintenance dialysis) w/ Al-related bone disease, dialysis encephalopathy or Al-related anemia. Diagnosis of Fe or Al overload.
Click to view Desferal detailed prescribing information
Dosage/Direction for Use
Chronic Fe overload 20-60 mg/kg daily. Patients w/ serum ferritin level <2,000 ng/mL 25 mg/kg/day; serum ferritin level 2,000-3,000 ng/mL 35 mg/kg/day; higher serum ferritin up to 55 mg/kg/day. Acute Fe poisoning Up to 80 mg/kg/day. Chronic Al overload 5 mg/kg once wkly. Test for Fe overload 500 mg IM. Infusion test for Al overload 5 mg/kg as slow IV infusion.
Click to view Desferal detailed prescribing information
Overdosage
View Desferal overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity.
Click to view Desferal detailed prescribing information
Special Precautions
Rapid IV infusion may lead to hypotension & shock (eg, flushing, tachycardia, circulatory collapse & urticaria). Disturbances of vision & hearing. Monitor for changes in renal function. Growth retardation (especially in patients <3 yr). Monitor body wt & longitudinal growth every 3 mth in ped patients. Acute resp distress syndrome, following high IV doses. Increased susceptibility to infections eg, w/ Yersinia enterocolitica & Yersinia pseudotuberculosis. Rare cases of mucormycosis. Cardiac impairment w/ high doses of vit C. In patients w/ Al-related encephalopathy, high doses may exacerbate neurological dysfunction. Treatment of Al overload may result in hypocalcemia & aggravation of hyperparathyroidism. Renal impairment. May affect ability to drive or operate machinery. Pregnancy & lactation.
Click to view Desferal detailed prescribing information
Adverse Reactions
Arthralgia, myalgia; inj site reaction eg, pain, swelling, infiltration, erythema, pruritus, eschar, crust. Headache; nausea; urticaria; growth retardation & bone disorder (eg, metaphyseal dysplasia) in higher doses & young childn; pyrexia.
Click to view Desferal detailed prescribing information
Drug Interactions
Risk of temporary impairment of consciousness w/ prochlorperazine. Increased risk of impairment of cardiac function w/ high dose vit C. Gallium-67 imaging results may be distorted.
Click to view Desferal detailed prescribing information
Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Desferal detailed prescribing information
Storage
View Desferal storage conditions for details to ensure optimal shelf-life.
Description
View Desferal description for details of the chemical structure and excipients (inactive components).
Action
View Desferal mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Antidotes & Detoxifying Agents
ATC Classification
V03AC01 - deferoxamine ; Belongs to the class of iron chelating agents. Used in the management of iron poisoning.
Presentation/Packing
Form
Desferal powd for soln for inj 500 mg
Packing/Price
10 × 1's
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Already a member? Sign in
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Already a member? Sign in