Rapid IV infusion may lead to hypotension & shock (eg, flushing, tachycardia, circulatory collapse & urticaria). Disturbances of vision & hearing. Monitor for changes in renal function. Growth retardation (especially in patients <3 yr). Monitor body wt & longitudinal growth every 3 mth in ped patients. Acute resp distress syndrome, following high IV doses. Increased susceptibility to infections eg, w/ Yersinia enterocolitica
& Yersinia pseudotuberculosis
. Rare cases of mucormycosis. Cardiac impairment w/ high doses of vit C. In patients w/ Al-related encephalopathy, high doses may exacerbate neurological dysfunction. Treatment of Al overload may result in hypocalcemia & aggravation of hyperparathyroidism. Renal impairment. May affect ability to drive or operate machinery. Pregnancy & lactation.