Agencia Lei Va Hong
Concise Prescribing Info
Irinotecan HCl trihydrate
Treatment of advanced colorectal cancer in combination w/ 5-fluorouracil (5-FU) & folinic acid in patient w/o prior chemotherapy for advanced disease or as single agent in patient who failed to respond to an established 5-FU-containing treatment regimen. In combination w/ cetuximab for treatment of epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer after failure of irinotecan-containing cytotoxic therapy. In combination w/ 5-FU, folinic acid & bevacizumab for 1st-line treatment of metastatic carcinoma of the colon or rectum.
Dosage/Direction for Use
Adult Monotherapy Previously treated patient 350 mg/m2 IV infusion over 30-90 min every 3 wk. Combination therapy Previously untreated patient 180 mg/m2 IV infusion over 30-90 min every 2 wk, followed by infusion w/ folinic acid & 5-FU.
Chronic inflammatory bowel disease &/or bowel obstruction. Severe bone marrow failure. Concomitant use w/ St. John's wort. Bilirubin level >3 times ULN. Pregnancy & lactation. Childn.
Special Precautions
Patients w/ increased risk of diarrhoea eg, those w/ previous abdominal/pelvic radiotherapy. Monitor CBC wkly. Resp disorders. Fructose intolerance. Renal or hepatic impairment. Elderly. May impair ability to drive or operate machinery.
Adverse Reactions
Diarrhoea, nausea, vomiting, fever, neutropenia, anaemia, thrombocytopenia, abdominal pain, conjunctivitis, rhinitis, hypotension, vasodilatation, sweating, chills, malaise, dizziness, visual disturbances, miosis, lacrimation, increased salivation, reversible alopecia.
Drug Interactions
Neuromuscular blockers eg, suxamethonium; carbamazepine, phenobarb, phenytoin, rifampicin; ketoconazole.
ATC Classification
L01XX19 - irinotecan ; Belongs to the class of other antineoplastic agents. Used in the treatment of cancer.
Irinotesin infusion conc 20 mg/mL
2 mL x 1's;5 mL x 1's
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