Concise Prescribing Info
Treatment of type 2 DM when diet, physical exercise & wt reduction alone have not been able to control blood sugar levels.
Dosage/Direction for Use
1 mg once daily, may be increased after 1-2 wk. Max dose: 6 mg/day.
Should be taken with food: Take immediately before or during breakfast, or the 1st main meal of the day. Do not skip meals.
Hypersensitivity to glimepiride or other sulfonylureas or sulfonamides. Insulin-dependent DM, diabetic ketoacidosis or diabetic coma. Severe kidney or liver disease. Pregnancy & lactation.
Special Precautions
Recovering from injury, operation, infections w/ fever or from other form of stress. G6PD deficiency. Increased risk of hypoglycemia. Regular monitoring of blood & urine glucose levels, blood cell levels & liver function. Intolerance to some sugars. May affect ability to drive or operate machinery. Not recommended in childn <18 yr.
Adverse Reactions
Allergic reactions; jaundice, cholestasis, hepatitis or liver failure; itching, rash, hives & increased photosensitivity. Severe hypoglycaemia including loss of consciousness, seizures or coma.
Drug Interactions
Increased risk of hypoglycemia w/ insulin, metformin, phenylbutazone, azopropazone, oxyphenbutazone, aspirin-like drugs, long acting sulfonamides, tetracyclines, chloramphenicol, fluconazole, miconazole, quinolones, clarithromycin, anabolics, male sex hormone replacement therapy, fluoxetine, MAOIs, fibrates, ACE inhibitors, allopurinol, probenecid, sulfinpyrazone, cyclophosphamide, ifosfamide, trofosfamide, fenfluramine, pentoxifylline, tritoqualine, sympatholytics. Increased risk of hyperglycemia w/ oestrogens, progestogens, thiazide diuretics, levothyroxine, glucocorticoids, chlorpromazine & other phenothiazine derivatives, adrenaline & sympathomimetics, nicotinic acid, laxatives, phenytoin, barbiturates, acetazolamide, diazoxide, rifampicin, glucagon. H2-antagonist, β-blockers, clonidine, guanethidine, reserpine & alcohol can increase or decrease the effect of glimepiride. Glimepiride may either increase or weaken the effect of warfarin.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.
NIKP-Glimepiride tab 3 mg
10 × 10's
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