Standard dose: Adult & childn >12 yr 1-2 g once daily, may be raised to 4 g once daily in severe cases. Neonate, infant & childn 15 days-12 yr 20-80 mg/kg once daily. Neonate ≤14 days 20-50 mg/kg once daily. Max dose: 50 mg/kg. IV doses of ≥50 mg/kg should be given by infusion over at least 30 min. Meningitis Infant & childn Initially 100 mg/kg (max of 4 g) once daily. Lyme borreliosis Adult & childn 50 mg/kg (max of 2 g) once daily for 14 days. Gonorrhea 250 mg single IM dose. Peri-op prophylaxis 1-2 g single dose, 30-90 min prior to surgery.
Immune-mediated hemolytic anaemia. Clostridium difficile associated diarrhea. Institute appropriate fluid & electrolyte management, protein supplementation, antibiotic treatment of C. difficile & surgical evaluation. Superinfections w/ non-susceptible microorganisms may occur. Do not mix or administer to any patient simultaneously w/ Ca-containing soln. Pancreatitis. Perform regularly CBC during prolonged treatment. Pregnancy & lactation. Neonates.
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