Rocephin

Rocephin

ceftriaxone

Manufacturer:

Roche

Distributor:

Firma Chun Cheong
/
DKSH
Concise Prescribing Info
Contents
Ceftriaxone disodium
Indications/Uses
Sepsis, meningitis, disseminated Lyme borreliosis; UTI; abdominal, renal, resp tract (particularly pneumonia), ear, nose & throat, genital (including gonorrhoea) infections; infections of bones, joints, soft tissue, skin & wounds; infections in patients w/ impaired defense mechanisms. Pre-op prophylaxis of infections.
Dosage/Direction for Use
Standard dose: Adult & childn >12 yr 1-2 g once daily, may be raised to 4 g once daily in severe cases. Neonate, infant & childn 15 days-12 yr 20-80 mg/kg once daily. Neonate ≤14 days 20-50 mg/kg once daily. Max dose: 50 mg/kg. IV doses of  ≥50 mg/kg should be given by infusion over at least 30 min. Meningitis Infant & childn Initially 100 mg/kg (max of 4 g) once daily. Lyme borreliosis Adult & childn 50 mg/kg (max of 2 g) once daily for 14 days. Gonorrhea 250 mg single IM dose. Peri-op prophylaxis 1-2 g single dose, 30-90 min prior to surgery.
Contraindications
Hypersensitivity to cephalosporins, penicillin. Hyperbilirubinaemic & preterm newborns. Neonates (≤28 days) requiring treatment w/ Ca-containing IV soln.
Special Precautions
Immune-mediated hemolytic anaemia. Clostridium difficile associated diarrhea. Institute appropriate fluid & electrolyte management, protein supplementation, antibiotic treatment of C. difficile & surgical evaluation. Superinfections w/ non-susceptible microorganisms may occur. Do not mix or administer to any patient simultaneously w/ Ca-containing soln. Pancreatitis. Perform regularly CBC during prolonged treatment. Pregnancy & lactation. Neonates.
Adverse Reactions
GI complaints eg, loose stools or diarrhea, nausea, vomiting, stomatitis & glossitis. Eosinophilia, leukopenia, granulocytopenia, hemolytic anemia, thrombocytopenia. Exanthema, allergic dermatitis, pruritus, urticaria, edema.
Drug Interactions
Precipitation w/ Ca-containing soln eg, Hartmann's & Ringer's soln. Incompatible w/ amsacrine, vancomycin, fluconazole & aminoglycosides.
MIMS Class
ATC Classification
J01DD04 - ceftriaxone ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
IV: A, IM: P1, A
Presentation/Packing
Form
Rocephin IV inj 1 g/10 mL
Packing/Price
1's
Form
Rocephin IV inj 500 mg/5 mL
Packing/Price
1's
Form
Rocephin IM inj 250 mg/2 mL
Packing/Price
1's
Form
Rocephin IM inj 1 g/3.5 mL
Packing/Price
1's
Form
Rocephin IV inj 250 mg/5 mL
Packing/Price
1's
Form
Rocephin IM inj 500 mg/2 mL
Packing/Price
1's
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