Tarceva特羅凱

Tarceva

erlotinib

Manufacturer:

Roche

Distributor:

Firma Chun Cheong
/
DKSH
Concise Prescribing Info
Contents
Erlotinib
Indications/Uses
1st-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) w/ epidermal growth factor receptor (EGFR) activating mutations. Monotherapy for maintenance treatment of locally advanced or metastatic NSCLC w/ stable disease after 4 cycles of standard platinum-based 1st-line chemotherapy. Treatment of locally advanced or metastatic NSCLC after failure of at least 1 prior chemotherapy regimen. In combination w/ gemcitabine, indicated for metastatic pancreatic cancer.
Dosage/Direction for Use
NSCLC 150 mg once daily. Pancreatic cancer 100 mg once daily.
Administration
Should be taken on an empty stomach: Take at least 1 hr before or 2 hr after meals.
Special Precautions
Interstitial lung disease, severe or persistent diarrhoea, nausea, anorexia or vomiting, associated w/ dehydration. Perform periodic liver function testing; GI perforation, severe bullous, blistering or exfoliating conditions. Acute/worsening ocular disorders. Concomitant w/ CYP3A4 substrates & modulators. Hepatic & severe renal impairment. Cigarette smoking. Pregnancy & lactation. Childn <18 yr.
Adverse Reactions
Rash, diarrhoea, anorexia, fatigue, dyspnea, cough, nausea, infection, vomiting, stomatitis, pruritus, dry skin, keratoconjunctivitis sicca, abdominal pain. Decreased wt, pyrexia, depression, dyspepsia, headache, alopecia, neuropathy, flatulence, rigors.
Drug Interactions
Potent CYP3A4 inhibitors eg, ketoconazole, combined CYP3A4/CYP1A2 inhibitors, CYP3A4 inducers eg, rifampicin. Drugs that reduce gastric acid production, including PPIs & H2-receptor antagonist (eg, omeprazole, ranitidine), coumarin-derived anticoagulants including warfarin, statins.
ATC Classification
L01XE03 - erlotinib ; Belongs to the class of protein kinase inhibitors, other antineoplastic agents. Used in the treatment of cancer.
Presentation/Packing
Form
Tarceva film-coated tab 150 mg
Packing/Price
30's
Form
Tarceva film-coated tab 25 mg
Packing/Price
30's
Form
Tarceva film-coated tab 100 mg
Packing/Price
30's
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