Generic Medicine Info
Indications and Dosage
Susceptible infections
Adult: Equivalent dose of oleandomycin 1-2 g/day in divided doses.
Child: Equivalent dose of oleandomycin 25-45 mg/kg/day.
Should be taken on an empty stomach.
Hypersensitivity. Patients who previously developed liver disorders while receiving the drug.
Special Precautions
Hepatic or renal impairment; predisposition to prolongation of QT interval; history of arrhythmias. Monitor LFT if used for >14 days or repeated courses used.
Adverse Reactions
GI disturbances; hypersensitivity reactions.
Potentially Fatal: Stevens-Johnson syndrome; toxic epidermal necrolysis; hepatotoxicity; arrhythmias.
Drug Interactions
Increased plasma concentrations of calcium channel blockers, bromocriptine, aprepitant, opioids, carbamazepine, etoposide, warfarin, aminophylline, theophylline, carbamazepine, ciclosporin, methylprednisolone, toremifene, benzodiazepines and tacrolimus. Increased risk of hepatotoxicity with rifampicin. Increased risk of ergotism with ergot alkaloids.
Potentially Fatal: Increased risk of ventricular arrhythmias with astemizole, terfenadine, disopyramide, diltiazem, verapamil, mizolastine and cisapride. Increased plasma concentration of cabergoline. Increased risk of severe pruritus and cholestatic jaundice with oral contraceptives and hormonal replacement therapy. Increased risk of cardiotoxicity with pimozide. Increased concentrations with sirolimus. Increased risk of respiratory depression with alfentanil.
Lab Interference
May interfere with measurements of urinary catecholamines and 17-hydroxycorticosteroids. False elevation of serum aspartate aminotransferase (AST) values when measured colorimetrically.
Mechanism of Action: Troleandomycin, a prodrug of oleandomycin, reversibly binds to 50S subunit of bacterial ribosome blocking the transpeptidation and inhibiting protein synthesis of susceptible bacteria thus inhibiting cell growth. It has general properties similar to erythromycin but is less effective in activity than erythromycin. 1.18g of troleandomycin is approximately equivalent to 1g of oleandomycin.
Absorption: Rapid and complete absorption. Peak plasma concentration of oleandomycin: 2 hr.
Excretion: Excreted in faeces and bile.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Troleandomycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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