Patient suffering from blockage of bladder, digestive system obstruction; reflux disease (including heartburn) or hiatus hernia; autonomic neuropathy; angioedema; preexisting abnormal ECG; high potassium. Concomitant w/ aspirin, ibuprofen or other NSAIDs; biphosphonates; medicines that may decrease the removal of Vesicare from the body. May affect ability to drive or operate machinery. Pregnancy & lactation.